| 100% | EDNA | 4 | Creator of Jett in ''Giant'' |
| 74% | ELSA | 4 | Creator of the giant snowman Marshmallow in "Frozen" |
| 59% | SNL | 3 | Creator of sketches, in brief |
| 58% | LEAR | 4 | Creator of "All in the Family" |
| 58% | RIOTER | 6 | Creator of mayhem in the streets |
| 57% | ARIEL | 5 | Creator of the tempest in "The Tempest" |
| 57% | DIOR | 4 | Creator of the "New Look" in fashion |
| 56% | LOUISAMAYALCOTT | 15 | Creator of the March family in ''Little Women'' |
| 55% | CICADAS | 7 | Creators of much buzz in the spring of 2021 |
| 55% | GROPIUS | 7 | Walter __, creator of the Bauhaus in Weimar |
| 55% | BRAHMA | 6 | The creator of the universe in Hinduism |
| 54% | DALI | 4 | Creator of a surreal dream sequence in Hitchcock’s “Spellbound” |
| 54% | ROCS | 4 | Giants of the sky, in myth |
| 52% | TREX | 4 | Creator of ripples in a water glass, in a classic movie scene |
| 52% | ALCOTT | 6 | Creator of the characters added in 17-, 28-, 44- and 57-Across |
| 52% | RICARD | 6 | Paul —, Marseille-born creator of an eponymous pastis in 1932 |
| 52% | COLOSSEUM | 9 | Giant historical stadium in the middle of Rome |
| 52% | BIOGEN | 6 | Giant in the development of neurological disease therapies |
| 52% | BASILISK | 8 | Giant serpent held in the Chamber of Secrets |
| 52% | IZANAGI | 7 | Creator god of the islands in Japanese mythology |
| 51% | SONY | 4 | Creator of AIBO, now in the Carnegie Mellon University Robot Hall of Fame |
| 51% | TITANS | 6 | Giant family of pre-Olympian gods in Greek myths |
| 51% | BEHEMOTH | 8 | Giant Biblical beast mentioned in the Book of Job |
| 51% | HUDSON | 6 | Giant square-shaped bay in the middle of Canada |
| 51% | ALOU | 4 | Surname of three Giants outfielders in 1963 |
| 51% | ALOU | 4 | Name of three Giants outfielders in 1963 |
| 51% | BROBDINGNAG | 11 | Land of giants in "Gulliver's Travels" |
| 50% | OSSA | 4 | Peak in the mythical war of the Giants |
| 50% | ENTS | 4 | Tree giants in The Lord of the Rings |
| 49% | ROWANATKINSON | 13 | Creator of "Mr. Bean" who plays 29-Across in a spy spoof franchise (2 wds.) |