| 100% | SETHMACFARLANE | 14 | Creator of the American animated sitcom "Family Guy" who also voices other characters of the show: 2 wds. |
| 55% | SETHMACFARLANE | 14 | Five-time Grammy nominee who is also the creator of the animated sitcom "Family Guy" (2 wds.) |
| 52% | JUSTINROILAND | 13 | American actor, who is the co-creator of "Rick and Morty", and also voices its two main characters : 2 wds. |
| 49% | PETERGRIFFIN | 12 | The main character and father of the family in the American sitcom, "Family Guy": 2 wds. |
| 45% | LARRYDAVID | 10 | One of the co-creators of "Seinfeld" who also voiced George Steinbrenner on the show: 2 wds. |
| 43% | KENYABARRIS | 11 | Creator of "Black-ish" who based the show on his real-life family: 2 wds. |
| 41% | SMALLWONDER | 11 | 1985 American sci-fi sitcom about the family of an engineer who creates a human girl-robot Vicki: 2 wds. |
| 41% | WALTERMURPHY | 12 | Composer of the theme music for the American sitcom, "Family Guy": 2 wds. |
| 40% | MANDYMOORE | 10 | Singer of the hit 2000 single "I Wanna Be With You", who also voiced the role of Rapunzel in the animated film "Tangled": 2 wds. |
| 40% | SETHMACFARLANE | 14 | "Family Guy" creator who wore a motion-capture suit to portray the title character in "Ted": 2 wds. |
| 40% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 39% | MATTGROENING | 12 | The Simpsons creator who is also the creator of the TV series "Disenchantment": 2 wds. |
| 39% | THESIMPSONS | 11 | Fox animated sitcom in which 17-Across voices the recurring character Fat Tony: 2 wds. |
| 39% | CLINTEASTWOOD | 13 | American actor who has also served as the Mayor of Carmel: 2 wds. |
| 39% | MIRAINAGASU | 11 | American figure skater and Olympian who participated in season 26 of the TV show "Dancing with the Stars": 2 wds. |
| 39% | SIMONEBILES | 11 | American artistic gymnast and Olympian who participated in season 24 of the TV show "Dancing with the Stars": 2 wds. |
| 39% | NORMANLEAR | 10 | Creator of TV's "All in the Family" who received the Woody Guthrie Prize in 2017: 2 wds. |
| 39% | MELBLANC | 8 | The voice of 15-Across and many other Looney Tunes characters: 2 wds. |
| 38% | JAMESCORDEN | 11 | "The Late Late Show" host who voices the title character in 18-Across: 2 wds. |
| 38% | DOROTHYHAMILL | 13 | Retired American figure skater and Olympian who participated in season 16 of the TV show "Dancing with the Stars": 2 wds. |
| 38% | SETH | 4 | ___ MacFarlane, creator of the animated show "Family Guy" |
| 38% | CHANNINGTATUM | 13 | "The Vow'' actor who voices one of the lead characters in "Smallfoot'': 2 wds. |
| 38% | ALTONBROWN | 10 | American chef, who is the host of popular shows like "Good Eats" and "Iron Chef America": 2 wds. |
| 38% | MARIOPUZO | 9 | American author of "The Godfather" who also wrote the screenplay for 1978 film "Superman": 2 wds. |
| 37% | JIMMYKIMMEL | 11 | American late night show host who was the co-host of Comedy Central's "The Man Show": 2 wds. |
| 37% | JOHNSTEINBECK | 13 | American author of "The Grapes of Wrath" who also wrote the screenplay for "Viva Zapata!": 2 wds. |
| 37% | PETER | 5 | ___ Griffin, popular television character voiced by Seth MacFarlane in the animated sitcom "Family Guy" |
| 37% | KALEYCUOCO | 10 | "The Flight Attendant" actress who voices the title character on HBO Max's animated "Harley Quinn": 2 wds. |
| 36% | BUTTERSSTOTCH | 13 | Character from "South Park," who is 43-Across's friend and is the sweet guy of the bunch: 2 wds. |
| 36% | GEORGEMURPHY | 12 | American actor who served as the U.S. Senator from California and was also included in the Hollywood Walk of Fame: 2 wds. |