| 100% | THEREALONEALS | 13 | Current ABC sitcom starring Martha Plimpton: 3 wds. |
| 51% | ABOUTABOY | 9 | Current NBC sitcom starring Minnie Driver as a single mom: 3 wds. |
| 49% | SUPERFUNNIGHT | 13 | ABC sitcom created by and starring 18-Across: 3 wds. |
| 45% | MODERNFAMILY | 12 | ABC sitcom starring 49-Across: 2 wds. |
| 42% | SAMANTHAWHO | 11 | 2007-2009 ABC sitcom starring Christina Applegate as a recovering amnesiac: 2 wds. |
| 41% | THEMIDDLE | 9 | ABC sitcom starring 16-Across and 33-Across in its ninth and final season (2 wds.) |
| 41% | TROPHYWIFE | 10 | ABC sitcom starring Malin Akerman and Bradley Whitford which was canceled after one season: 2 wds. |
| 40% | UPALLNIGHT | 10 | NBC sitcom starring 15-/50-Across as a new mom: 3 wds. |
| 40% | MADABOUTYOU | 11 | Recently rebooted 1990s sitcom starring Helen Hunt and Paul Reiser: 3 wds. |
| 39% | SINGLEPARENTS | 13 | ABC sitcom about divorced moms and dads starring 18-Across and 41-Across (2 wds.) |
| 39% | THEGOODPLACE | 12 | 2016-2020 NBC afterlife sitcom starring Kristen Bell and Ted Danson: 3 wds. |
| 39% | THEGOODDOCTOR | 13 | ABC drama starring Freddie Highmore as physician Shaun Murphy: 3 wds. |
| 39% | BIGBANGTHEORY | 13 | CBS sitcom starring Jim Parsons as a brainy Caltech physicist, with "The": 3 wds. |
| 39% | WIFEANDKIDS | 11 | "My ___," sitcom starring Damon Wayans in which Sofia Vergara cameoed as Selma: 3 wds. |
| 38% | ELLENDEGENERES | 14 | ABC sitcom star |
| 38% | THEGOODWIFE | 11 | CBS legal drama for which Martha Plimpton won an Outstanding Guest Actress Emmy: 3 wds. |
| 38% | THEGOLDENGIRLS | 14 | Sitcom starring 29-Across as Rose Nylund (3 wds.) |
| 38% | HOTINCLEVELAND | 14 | Sitcom starring 29-Across as Elka Ostrovsky (3 wds.) |
| 37% | ARRESTED | 8 | "___ Development," sitcom starring Jason Bateman, that got "canceled too soon," after only 4 seasons: 3 wds. |
| 37% | THEGOODPLACE | 12 | Sitcom starring Ted Danson as an immortal architect (3 wds.) |
| 37% | SHAKEITUP | 9 | Chicago-based 2010-2013 sitcom starring Zendaya: 3 wds. |
| 37% | BIGBANGTHEORY | 13 | "The ___," sitcom starring Jim Parsons which had a Halloween episode titled "The Middle-Earth Paradigm": 3 wds. |
| 36% | BLACKISH | 8 | ABC sitcom starring Tracee Ellis Ross: Hyph. |
| 34% | BOY | 3 | "___ Meets World" (former ABC sitcom starring Ben Savage) |
| 34% | SINGLEPARENTS | 13 | ABC sitcom with an ensemble cast: 2 wds. |
| 34% | MOM | 3 | Current CBS sitcom starring Anna Faris |
| 34% | SANFORDANDSON | 13 | Sitcom starring Redd Foxx and Demond Wilson that premiered on January 14, 1972 (3 wds.) |
| 34% | JUSTSHOOTME | 11 | Sitcom starring David Spade that debuted in 1997 and ran for seven seasons (3 wds.) |
| 34% | THEODDCOUPLE | 12 | 2015 American sitcom starring Matthew Perry and Thomas Lennon which is about two friends who learn to overcome their differences: 3 wds. |
| 34% | THEGOODDOCTOR | 13 | ABC medical drama series starring Freddie Highmore: 3 wds. |