| 100% | SCULLY | 6 | Dana __; an FBI agent and doctor on The X-Files |
| 44% | SCULLY | 6 | FBI agent Dana ___, protagonist of "The X-Files" |
| 39% | MULDER | 6 | FBI agent Fox ___, protagonist of "The X-Files" |
| 38% | MULDER | 6 | Agent on "The X-Files" |
| 38% | DONTPROBETHATGUY | 16 | Shout to an FBI agent investigating the wrong fellow? |
| 38% | ANDERSON | 8 | Gillian __ starred in The X Files and The Fall |
| 37% | DANA | 4 | Agent Scully on "The X-Files" |
| 36% | KALPENN | 7 | "Designated Survivor" actor who plays an FBI agent on 34-Across (2 wds.) |
| 36% | STANAKATIC | 10 | Former "Castle" star who's now playing an FBI agent on "Absentia": 2 wds. |
| 35% | MULDER | 6 | FBI Special Agent Fox __ from The X-Files |
| 35% | DANA | 4 | Agent ___ Scully on "The X-Files" |
| 34% | FBI | 3 | Employer of Mulder and Scully on "The X-Files": Abbr. |
| 34% | VOTED | 5 | Put an X in the box on election day |
| 33% | DUCHOVNY | 8 | David, star of The X-Files and Californication |
| 33% | BOWLASTRIKE | 11 | Earn an X on the scorecard |
| 33% | MEDIC | 5 | Doctor on the battlefield |
| 33% | BALTIMOREMD | 11 | Doctor on The Wire? |
| 33% | ALEX | 4 | ___ Cross, fictional former FBI agent and psychologist created by James Patterson who is the protagonist in many of his books |
| 32% | ICHAT | 5 | Old instant messaging app used on the Mac OS X and replaced by "Messages" in 2012 |
| 32% | MCCOY | 5 | Doctor on the starship Enterprise |
| 32% | OLIVIAMUNN | 10 | The Daily Show correspondent who went on to star in an X-Men movie |
| 32% | AGONY | 5 | "The ___ and the Ecstasy" (Charlton Heston film based on an Irving Stone novel) |
| 32% | FBI | 3 | Crime-fighting organization featured on "The X-Files" and "Criminal Minds": Abbr. |
| 32% | OPTIN | 5 | Click on an "I agree to the terms and conditions" box, say |
| 32% | AXES | 4 | The "X" and "Y" lines on a graph |
| 32% | HERBALPERT | 10 | Only musician to hit #1 on the Billboard Hot 100 as both a vocalist and an instrumentalist |
| 32% | TEMPLEGRANDIN | 13 | 2010 biographical drama film based on the life of an American scientist and autism advocate: 2 wds. |
| 31% | DANA | 4 | Agent Scully played by Gillian Anderson on "The X-Files" |
| 31% | BOOKLOVERS | 10 | Emily Henry novel about a literary agent and an editor who meet cute while on vacation (2 wds.) |
| 31% | BEAST | 5 | "Beauty and the ___," an animated musical romantic film based on a French fairy tale |