| 100% | LOSS | 4 | Datum for the second column |
| 57% | ANEW | 4 | For the second time |
| 54% | HELLOAGAIN | 10 | "Greetings for the second time!" |
| 53% | GLORYHOLE | 9 | Nickname for the second glassblowing furnace |
| 52% | AFTER | 5 | Caption for the second of two photos |
| 52% | ASSET | 5 | One for the plus column |
| 51% | OPT | 3 | "I'd rather ___ for the second one" (choose) |
| 51% | DIASTOLIC | 9 | Term for the second (lower) blood pressure number |
| 51% | INFANTA | 7 | Title for the second daughter of Spanish royalty |
| 51% | WEBB | 4 | Telescope named for the second administrator of NASA |
| 51% | NAY | 3 | One for the "no" column |
| 50% | STHELENA | 8 | Island where Napoleon was exiled for the second time |
| 50% | POKERPHASE | 10 | The second round of betting, for one? |
| 50% | LAKE | 4 | Great ___, location for the second task of the Triwizard tournament |
| 49% | SYS | 3 | The second "S" in MS-DOS, for short |
| 48% | DOS | 3 | Heading for the first of two columns |
| 47% | AUTO | 4 | What the second "A" in "NASCAR" stands for |
| 47% | DISC | 4 | What the second "D" in "DVD" stands for |
| 47% | ONCE | 4 | What the second "O" of "YOLO" stands for |
| 47% | AUG | 3 | Alphabetically it's the second month, for short |
| 47% | AARON | 5 | First name for the third second-in-command |
| 47% | ONCE | 4 | What the second "O" in "YOLO" stands for |
| 47% | MINES | 5 | Searches for the useful parts of, as data |
| 47% | BETAS | 5 | Test releases of software, named for the second letter of the Greek alphabet |
| 47% | DEANRUSK | 8 | U.S. secretary of state tied for the second-longest time in office |
| 47% | MEL | 3 | Gibson who won two Oscars in 1996 for the second movie he directed |
| 47% | NORTH | 5 | What the second letter of 10-Down stands for |
| 47% | FRIEND | 6 | What the second letter of 7-Down stands for |
| 46% | THETA | 5 | Second letter in the Greek for "Athens" |
| 46% | TUE | 3 | Second day of the workweek, for short |