| 100% | IRISMURDOCH | 11 | Dench and Winslet, in a 2001 biopic |
| 74% | IRIS | 4 | 2001 biopic featuring both Judi Dench and Kate Winslet in the title role |
| 71% | IRIS | 4 | Novelist Murdoch who was played by Kate Winslet and Judi Dench in a 2001 biopic |
| 58% | IRIS | 4 | 2001 film in which Kate Winslet and Judi Dench played the title role |
| 56% | ALI | 3 | Boxer played by Will Smith in a 2001 biopic |
| 56% | ALI | 3 | Boxer portrayed by Will Smith in a 2001 biopic |
| 55% | ALI | 3 | Boxer Muhammad played by Will Smith in a 2001 biopic |
| 55% | MUHAMMADALI | 11 | Boxer played by Will Smith in a 2001 biopic (2 wds.) |
| 53% | ALI | 3 | Whom Will Smith played in a 2001 sports biopic |
| 51% | IRIS | 4 | 2001 biopic about writer Murdoch, in which 15-Across played the title role (and received a Best Actress nomination) |
| 50% | IRIS | 4 | Part of the eye, or a 2001 Winslet biopic |
| 49% | SAMURAIJACK | 11 | Sword-wielding title character in a 2001-2004 and 2017 Cartoon Network series: 2 wds. |
| 49% | ALI | 3 | 2001 biopic starring Will Smith in the title role of a famous boxer |
| 47% | ABBA | 4 | Band whose songs are featured in a hit 2001 musical and 2018 movie |
| 46% | RICHARDSON | 10 | Miranda —, Best Actress in a Leading Role Oscar nominee for biopic Tom and Viv |
| 44% | COLEADS | 7 | Dench and Winslet, as 91 Across |
| 43% | AOL | 3 | Co. in a 2001 merger |
| 43% | ENRON | 5 | Company in a 2001 scandal |
| 43% | MISHIMA | 7 | 1985 biopic directed and co-written by Paul Schrader subtitled A Life in Four Chapters |
| 42% | ENRON | 5 | Company in a 2001-02 scandal |
| 42% | ENRON | 5 | Corporate giant in a 2001 bankruptcy |
| 42% | ENRON | 5 | Corporation in a 2001-02 scandal |
| 42% | IRIS | 4 | 2001 biopic starring Kate Winslet |
| 42% | AMELIE | 6 | Title girl in a 2001 French comedy |
| 42% | TEXACO | 6 | Company in a 2001 merger with Chevron |
| 42% | TWA | 3 | Co. in a 2001 merger with American |
| 42% | HAL | 3 | "Shallow" guy in a 2001 rom-com |
| 42% | ENRON | 5 | Houston-based company in a 2001 scandal |
| 42% | ENRON | 5 | Company in a 2001-02 business scandal |
| 41% | KPAX | 4 | Title planet in a 2001 Kevin Spacey movie |