| 100% | SHERLOCK | 8 | Detective in an Arthur Conan Doyle book: __ Holmes |
| 53% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 49% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle |
| 47% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 45% | SHERLOCK | 8 | BBC show based on a series of Arthur Conan Doyle books |
| 45% | SHERLOCK | 8 | Sir Arthur Conan Doyle's fictional detective |
| 44% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 43% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 42% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle, who you may associate with 20a, 33a, 42a, 9d, and 36d |
| 41% | SHERLOCKHOLMES | 14 | Fictional detective created by Arthur Conan Doyle: 2 wds. |
| 40% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 40% | ALLOSAURUS | 10 | Terror in Arthur Conan Doyle's "The Lost World" |
| 39% | HOLMES | 6 | Sherlock ___, Sir Arthur Conan Doyle's brilliant detective who is never seen without his signature deerstalker hat |
| 39% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 38% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |
| 38% | SCANDAL | 7 | "A ___ in Bohemia," Sherlock Holmes short story by Arthur Conan Doyle |
| 38% | SCARLET | 7 | A Study in __, 1887 Arthur Conan Doyle novel |
| 38% | SIR | 3 | Arthur Conan Doyle title |
| 38% | ASTUDYINSCARLET | 15 | Arthur Conan Doyle novel |
| 37% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |
| 37% | SHERLOCK | 8 | __ Holmes, character by Sir Arthur Conan Doyle |
| 37% | SCOTSMAN | 8 | Arthur Conan Doyle, e.g. |
| 37% | SIR | 3 | Arthur Conan Doyle's title |
| 37% | POISONDART | 10 | Cause of death in Sir Arthur Conan Doyle’s “The Sign of the Four” |
| 37% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 37% | LESTRADE | 8 | Fictional Scotland Yard inspector in stories by Arthur Conan Doyle involving Sherlock Holmes who first appeared in A Study in Scarlet |
| 37% | ACEVENTURA | 10 | Detective in an aloha shirt |
| 37% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 36% | SIR | 3 | Arthur Conan Doyle's title of respect |
| 36% | SIR | 3 | Title for Arthur Conan Doyle |