| 100% | ICANTOO | 7 | Determined response to a challenge (3 wds.) |
| 91% | ICANTOO | 7 | Determined response to a playground challenge (3 wds.) |
| 81% | ICANTOO | 7 | Playground response to a challenge (3 wds.) |
| 62% | ILLTRY | 6 | Response to a challenge |
| 60% | FRIEND | 6 | One response to a challenge |
| 59% | POSITIVESTRESS | 14 | Beneficial response to a challenging situation |
| 58% | IDO | 3 | Response to a court oath: 2 wds. |
| 58% | IDO | 3 | Response to a minister, sometimes: 2 wds. |
| 58% | IDO | 3 | Response to a marriage officiant: 2 wds. |
| 58% | CANSO | 5 | Response to a playground challenge |
| 57% | BLESSYOU | 8 | Response to a sneeze: 2 wds. |
| 57% | HAHA | 4 | Response to a joke: 2 wds. |
| 56% | OHSNAP | 6 | Response to a clever put-down: 2 wds. |
| 56% | HAHAHA | 6 | Desired response to a 3-Down |
| 55% | ITRY | 4 | Modest response to a compliment: 2 wds. |
| 55% | ITRY | 4 | Humble response to a compliment: 2 wds. |
| 55% | IBET | 4 | Skeptical response to a claim: 2 wds. |
| 54% | NAILEDIT | 8 | Sarcastic response to a spectacular failure (2 wds.) |
| 54% | YESSIR | 6 | Affirmative response to a male officer: 2 wds. |
| 54% | NOCOMMENT | 9 | Dismissive response to a reporter's question: 2 wds. |
| 54% | ITRY | 4 | Humble response to a compliment (2 wds.) |
| 53% | IDIDSO | 6 | Response to "You couldn't have!": 3 wds. |
| 52% | TOOSOON | 7 | Offended response to a joke about a recent tragedy: 2 wds. |
| 52% | SAYSYES | 7 | Gives the hoped-for response to a marriage proposal: 2 wds. |
| 52% | CANSO | 5 | Kid's response to a dare: 2 wds. |
| 52% | YESSIR | 6 | Recruit's response to a male drill sergeant's order: 2 wds. |
| 51% | IDO | 3 | Expected response to "Want a cupcake?": 2 wds. |
| 51% | ITSOPEN | 7 | "Come on in!" response to a doorbell: 2 wds. |
| 50% | IMISSYOU | 8 | Loving words to a far-away friend: 3 wds. |
| 50% | NOTATALL | 8 | Polite response to "Would this be an imposition?": 3 wds. |