| 100% | NNE | 3 | Direction that is the opposite of SSW |
| 66% | ANTONYM | 7 | Word that is the opposite of another |
| 66% | PRE | 3 | Prefix that is the opposite of "post" |
| 66% | YEAS | 4 | Votes that are the opposite of nays |
| 66% | ALKALINE | 8 | Batteries that are the opposite of acidic |
| 66% | NAYS | 4 | Negative votes that are the opposite of yeas |
| 65% | ACIDS | 5 | Caustic substances that are the opposites of bases |
| 65% | OUI | 3 | French word that is the opposite of 14-Across |
| 65% | NON | 3 | French word that is the opposite of 2-Down |
| 63% | LEFT | 4 | Direction that is opposite of right |
| 63% | LEFT | 4 | Direction that is opposite of "right" |
| 61% | ESE | 3 | Compass direction that's the opposite of WNW: Abbr. |
| 54% | SPEND | 5 | Be the opposite of 4-Down |
| 54% | NNE | 3 | On a compass, the opposite of SSW |
| 52% | ITALY | 5 | Where "caldo" is the opposite of cold |
| 51% | ENE | 3 | Direction that is opposite WSW: Abbr. |
| 51% | ANTONYM | 7 | A word whose meaning is the opposite of another |
| 50% | GRIN | 4 | Expression that seems like it would be the opposite of 5-Across? |
| 50% | LIGHT | 5 | It can be the opposite of either dark or heavy |
| 50% | ANTAGONIST | 10 | The opposite of one who is not against? |
| 50% | NNE | 3 | Direction opposite of SSW |
| 50% | DAYS | 4 | "... those were the best ___ of my life..." |
| 49% | ENE | 3 | Direction that's the reverse of WSW |
| 49% | NNE | 3 | Direction that's opposite SSW: Abbr. |
| 48% | BIZARROWORLD | 12 | DC Comics planet where things are the opposite of their equivalents on Earth |
| 48% | SUCROSE | 7 | Compound that is the main component of cane sugar |
| 48% | ORCA | 4 | Killer whale that is the largest species of dolphin |
| 48% | MOREL | 5 | Edible fungus that is the state mushroom of Minnesota |
| 48% | DRIVINGMISSDAISY | 16 | "Floral" film that was the Best Picture of 1989 |
| 48% | MOBILEALABAMA | 13 | City that was the first capital of French Louisiana |