| 100% | APATOW | 6 | Director of "The 40-Year-Old Virgin" and "This Is 40" |
| 75% | APATOW | 6 | "This Is 40" and "The 40-Year-Old Virgin" director Judd |
| 64% | APATOW | 6 | Judd, director of Knocked Up and This Is 40 |
| 63% | IJUSTMETYOU | 11 | "Hey, ___, and this is crazy ..." (start of the chorus in 40-Across): 4 wds. |
| 63% | APATOW | 6 | Judd who directed "This Is 40" and "The 40-Year-Old Virgin" |
| 63% | APATOW | 6 | Director of the 2012 comedy "This Is 40" |
| 59% | PAULRUDD | 8 | Star of Ant-Man and This Is 40 |
| 58% | NOISE | 5 | Despite being inducted in the Rock and Roll Hall of Fame last year, Radiohead still produces this, to many people |
| 57% | HURRICANE | 9 | The list of names for this type of meteorological feature will include Nana, Omar and Paulette this year |
| 57% | OTHER | 5 | "Of Love and ___ Demons," 1994 novel by Gabriel Garcia Marquez that tells the story of a 12 year old girl who is bitten by a dog |
| 56% | MISSYELLIOTT | 12 | 14-Across and 29-Across rapper in the Songwriters Hall of Fame who turns 50 years old this week (2 wds.) |
| 56% | RUDD | 4 | "The 40 Year Old Virgin" actor Paul |
| 56% | TREX | 4 | English rock band being inducted into the Rock and Roll Hall of Fame this year: 2 wds., abbr. |
| 55% | MANN | 4 | Leslie ___, an actress known for her roles in "This is 40" and "George of the Jungle" |
| 55% | STIRRUP | 7 | Three bones of the ear are hammer, anvil and this |
| 55% | SEED | 4 | Silene stenophylla produced the oldest - at about 32,000 years - one of these ever to have been successfully grown |
| 54% | RAMIS | 5 | Harold —, director of the films Groundhog Day, Year One and Caddyshack |
| 54% | ANDERSON | 8 | Lindsay —, director of the films Britannia Hospital and This Sporting Life |
| 54% | ROBREINER | 9 | Director of films LBJ and This Is Spinal Tap |
| 54% | ORGAN | 5 | The heart and liver are both examples of this |
| 54% | ANTELOPE | 8 | The impala and nyala are this kind of animal |
| 54% | NIAGARA | 7 | (3/6)"Our first stop is the ___ Falls. Fun fact: This 12,000 years old waterfall lies on the border between Ontario and New York!" |
| 54% | SOLAR | 5 | The sun and planets are a part of this system |
| 54% | ECLIPSE | 7 | This was Total and of the Heart, for Bonnie Tyler |
| 54% | KAT | 3 | Actress Dennings of "The 40-Year-Old Virgin" |
| 54% | COMPUTERS | 9 | Cyberphobia is the fear of technology and these |
| 54% | SHELLS | 6 | Conchology is the study of molluscs and these |
| 53% | GAMEOFTHRONES | 13 | Fantasy drama set in the fictional continents of Westeros and Essos which will air its final season this year (2019): 3 wds. |
| 53% | KEEPTHEFAITH | 12 | 1992 Bon Jovi album whose three Top 40 hits were the title track, "Bed of Roses," and "In These Arms" (3 wds.) |
| 53% | SEXCOMEDIES | 11 | "The 40-Year-Old Virgin" and "Knocked Up" |