| 100% | GOUT | 4 | Disease, especially of the big toe, caused by an excess of uric acid in the blood |
| 49% | PELLAGRA | 8 | Deficiency disease caused by a lack of nicotinic acid in the diet |
| 34% | CIRRHOSIS | 9 | Progressive disease of the liver sometimes caused by excessive alcohol |
| 34% | HYPOXEMIA | 9 | An abnormally low amount of oxygen in the blood |
| 32% | ECLIPSE | 7 | Shadow caused by the Moon passing in front of the Sun |
| 32% | VALLEY | 6 | Big dip in the landscape caused by river erosion |
| 32% | GOUT | 4 | Possible cause of pain in a big toe |
| 32% | SCORPIO | 7 | Eighth astrological sign symbolized by an arthropod for those born in the fall months of October-November |
| 31% | SINKHOLE | 8 | Pit in the ground caused by collapse of surface |
| 31% | AMORE | 5 | Cause of the moon hitting your eye like a big pizza pie, in song |
| 31% | DIURETIC | 8 | Drug that causes an increase in the flow of urine |
| 31% | ASS | 3 | Jawbone of an ___ (weapon used by Samson, in the Bible) |
| 31% | IRE | 3 | Cause of an increase in blood pressure, maybe |
| 31% | ELSA | 4 | Character voiced by Idina Menzel in "Frozen 2," one of the biggest hits of 2019 |
| 31% | NYU | 3 | Big Apple school attended by many of the characters in "Gossip Girl": Abbr. |
| 30% | HAEMOPHILIA | 11 | Inheritable disease characterized by loss of the normal clotting ability of blood |
| 30% | ACNE | 4 | Skin disorder caused by inflammation of the glands found chiefly in adolescents |
| 30% | SPAGHETTI | 9 | Cause of an accidental kiss in "Lady and the Tramp" |
| 30% | COUNTRYBLUES | 12 | Acoustic folk style of music in which the singer is accompanied by an acoustic guitar: 2 wds. |
| 30% | AMYDORRIT | 9 | Title character of an 1857 novel by Charles Dickens born and raised in the Marshalsea debtors' prison |
| 30% | GOUT | 4 | Big woe of the big toe |
| 30% | IONA | 4 | Island in the Inner Hebrides; site of an abbey founded by St Columba |
| 30% | ALICE | 5 | Woman in the title of an eighteen-minute protest anthem by Arlo Guthrie |
| 30% | DEATHS | 6 | Heart disease is the major cause of ___ in America |
| 30% | RENO | 4 | "Make the biggest little mistake of your life in ___" (tourism slogan in an Arrested Development gag) |
| 30% | SHARP | 5 | In music, an accidental that raises the pitch of the following note by one chromatic semitone |
| 29% | DWAYNEJOHNSON | 13 | Wrestler who went by The Rock, who is one of the biggest stars in Hollywood right now: 2 wds. |
| 29% | SEANPENN | 8 | Oscar winner who made his debut in an episode of Little House on the Prairie directed by his father |
| 29% | BUNION | 6 | Painful swelling of the big toe |
| 29% | BUNIONS | 7 | Joint swellings of the big toes |