| 100% | KELLYBUNDY | 10 | Ditzy character played by 15-/50-Across on "Married... with Children": 2 wds. |
| 51% | NEWTSCAMANDER | 13 | Character played by 15-Across in "Fantastic Beasts and Where to Find Them": 2 wds. |
| 49% | JOANCLAYTON | 11 | Character played by Tracee Ellis Ross on 17-Across: 2 wds. |
| 47% | ROSSGELLER | 10 | Geeky character played by David Schwimmer on "Friends": 2 wds. |
| 46% | SHELDONCOOPER | 13 | Geeky character played by Jim Parsons on "The Big Bang Theory": 2 wds. |
| 46% | STEVEURKEL | 10 | Geeky character played by Jaleel White on "Family Matters": 2 wds. |
| 46% | THEDOCTOR | 9 | Time Lord whose 11th incarnation was played by 15-Across on a long-running BBC sci-fi series: 2 wds. |
| 45% | JENNYWILDER | 11 | Character played by 24-Across/37-Across on "Little House on the Prairie" (2 wds.) |
| 45% | JESSEPINKMAN | 12 | Character played by Aaron Paul in "Breaking Bad", who was a crystal meth dealer and worked with the character played by 30-Across: 2 wds. |
| 45% | SIMONTEMPLAR | 12 | Character played by 24-Across/27-Across on the 1960s TV series "The Saint" (2 wds.) |
| 45% | PIPERCHAPMAN | 12 | Lead character played by Taylor Schilling on "Orange Is the New Black": 2 wds. |
| 43% | BRENDAWALSH | 11 | Character played by 24-Across/37-Across on "Beverly Hills, 90210" (2 wds.) |
| 43% | MARGARETBUNDY | 13 | The wife of Al Bundy on "Married... with Children," portrayed by Katey Sagal: 2 wds. |
| 43% | RAFESADLER | 10 | Character played by actor Thomas Brodie-Sangster in the British television serial "Wolf Hall" based on Hilary Mantel novels: 2 wds. |
| 43% | ARCHIEANDREWS | 13 | Comics character played by KJ Apa on "Riverdale" (2 wds.) |
| 43% | BETTYCOOPER | 11 | Comics character played by Lili Reinhart on "Riverdale" (2 wds.) |
| 42% | VERONICALODGE | 13 | Comics character played by Camila Mendes on The CW series "Riverdale" (2 wds.) |
| 42% | ARCHIEANDREWS | 13 | Comics character played by KJ Apa on The CW's "Riverdale" (2 wds.) |
| 42% | BETTYCOOPER | 11 | Comics character played by Lili Reinhart on The CW's "Riverdale" (2 wds.) |
| 42% | VERONICALODGE | 13 | Comics character played by Camila Mendes on The CW's "Riverdale" (2 wds.) |
| 42% | HARRYCALLAHAN | 13 | Police inspector played by 15-Across in "Sudden Impact": 2 wds. |
| 42% | DEANNATROI | 10 | "Star Trek" character played by Marina Sirtis, who serves as the ship's counselor on USS Enterprise-D: 2 wds. |
| 42% | CHRISSYSNOW | 11 | Roommate of Janet Wood and Jack Tripper played by 44-Across on 15-Across (2 wds.) |
| 42% | STARRCARTER | 11 | Character played by Amandla Stenberg in the movie adaptation of 30-Across: 2 wds. |
| 42% | SARAHCONNOR | 11 | Action hero played by 48-Across in a film series that began with 15-Across (2 wds.) |
| 41% | UNCLEJESSE | 10 | Role played by 18-Across on "Full House": 2 wds. |
| 41% | GLORIASTEINEM | 13 | Feminist journalist played by 15-Across and Alicia Vikander in a 2020 biopic based on the memoir "My Life on the Road" (2 wds.) |
| 41% | DRWATSON | 8 | Holmes' assistant, played by 29-Across on 47-Across: 2 wds. |
| 41% | DEREKMORGAN | 11 | Special agent played by 39-Across on 29-Across: 2 wds. |
| 40% | PHOEBEBUFFAY | 12 | Character played by Lisa Kudrow in "Friends": 2 wds. |