| 100% | EURYTHMICS | 10 | Duo who performed their song "Would I Lie to You?" to open the second MTV Video Music Awards, in 1985 |
| 51% | ROBERT | 6 | With 31-Across, singer who performed his song "Addicted to Love" to open the third MTV Video Music Awards, in 1986 |
| 51% | RODSTEWART | 10 | Singer who performed his song "Infatuation" to open the first MTV Video Music Awards, in 1984: 2 wds. |
| 39% | BLACKPINK | 9 | "How You Like That" band who won Song of Summer at the 2020 MTV Video Music Awards |
| 38% | BRITNEYSPEARS | 13 | Singer who won Video of the Year for "Piece of Me" at MTV Video Music Awards in 2008: 2 wds. |
| 38% | SILKSONIC | 9 | R & B duo who performed their #1 single "Leave the Door Open" at the Grammy Awards ceremony in 2021 (2 wds.) |
| 36% | RAIN | 4 | "___ On Me," song by Lady Gaga and Ariana Grande that won the MTV Video Music Award for Song of the Year in 2020 |
| 35% | SLEDGEHAMMER | 12 | Song that accounted for 9 of the 10 MTV Video Music Awards won by 17-Across in 1987 |
| 35% | GAGA | 4 | "Lady" who wore a meat dress to the MTV Video Music Awards |
| 35% | TIMBERLAKE | 10 | Justin ___, singer who won Video of the Year for "Mirrors" at MTV Video Music Awards in 2013 |
| 35% | AUSTINMAHONE | 12 | YouTube sensation who was the Artist to Watch at the 2013 MTV Video Music Awards: 2 wds. |
| 34% | PIECEOFME | 9 | Song by 32-Across that won three MTV Video Music Awards in 2008, including Video of the Year (3 wds.) |
| 34% | KATY | 4 | Singer ___ Perry who won Video of the Year Award for "Firework" at MTV Video Music Awards in 2011 |
| 34% | GAGA | 4 | Lady ___, singer who won the Video of the Year for "Bad Romance" at MTV Video Music Awards in 2011 |
| 34% | MILEYCYRUS | 10 | Singer who won Video of the Year for "Wrecking Ball" at MTV Video Music Awards in 2014: 2 wds. |
| 34% | FLY | 3 | "Learning to ___," Pink Floyd song that won Best Concept Video at the MTV Video Music Awards |
| 33% | PETERGABRIEL | 12 | "Big Time" singer who won 10 MTV Video Music Awards in 1987, the most wins ever in a single night: 2 wds. |
| 33% | GOODASHELL | 10 | Song on 46-Across's EP "Coconut Oil" that became a Billboard hit after she performed it at the 2019 MTV Video Music Awards (3 wds.) |
| 33% | MYHEAD | 6 | "Can't Get You Out of ___," hit song by Australian singer Kylie Minogue which won an MTV Video Music Award in 2002: 2 wds. |
| 33% | LALA | 4 | 2021 song by Alicia Keys and Swae Lee performed live for the first time at the MTV Video Music Awards |
| 32% | HORSE | 5 | "Dark ___," song by Katy Perry featuring Juicy J that won the MTV Video Music Award for Best Female Video in 2014 |
| 32% | JUICE | 5 | Song from 46-Across's album "Cuz I Love You" that won the 2019 Soul Train Music Award for Video of the Year |
| 31% | KANYE | 5 | Rapper West who interrupted Taylor Swift at the 2009 MTV Video Music Awards |
| 31% | COLDPLAY | 8 | "Orphans" band who won Best Rock at the 2020 MTV Video Music Awards |
| 30% | TEMPO | 5 | 46-Across song featuring Missy Elliott that was nominated for the 2019 MTV Video Music Award for Best Power Anthem |
| 30% | LADYGAGA | 8 | "Rain on Me" singer who won the MTV Tricon Award, Artist of the Year, and two other awards at the 2020 MTV Video Music Awards (2 wds.) |
| 30% | JENNIFERLOPEZ | 13 | "I'm Real" pop singer who received the 2018 MTV Video Vanguard Award, the first Latin artist to do so: 2 wds. |
| 30% | JUSTIN | 6 | With 33-Across, pop idol who was the Best New Artist at the 2010 MTV Video Music Awards |
| 30% | MEGANFOX | 8 | American actress who was in the music video of Eminem's "Love the Way You Lie": 2 wds. |
| 30% | CAMILACABELLO | 13 | "Señorita" singer who shared the 2019 MTV Video Music Award for Best Collaboration with 18-Across (2 wds.) |