| 100% | NAPOLEON | 8 | Dynamite character whose best friend is Pedro |
| 66% | DORATHEEXPLORER | 15 | Animated TV character whose best friend is Boots |
| 63% | SPONGEBOB | 9 | First name of the cartoon character whose best friend is Patrick Star |
| 53% | FRODO | 5 | Hobbit whose best friend is Sam |
| 53% | KEN | 3 | Doll whose best friend is Allan |
| 52% | DORA | 4 | Cartoon explorer whose best friend is Boots |
| 52% | DORA | 4 | Cartoon girl whose best friend is Boots |
| 52% | HEIDI | 5 | Literary heroine whose best friend is a goatherd |
| 52% | YOGI | 4 | Animated bear whose best friend is Boo-Boo |
| 50% | DORA | 4 | Cartoon explorer whose best friend is a monkey named Boots |
| 49% | CHUCKIEFINSTER | 14 | Nickelodeon cartoon character with red hair whose best friend is Tommy Pickles (2 wds.) |
| 48% | PRINCESSMERIDA | 14 | Disney cartoon character with red hair whose best friend is a horse named Angus (2 wds.) |
| 47% | ELMO | 4 | Red Muppet on "Sesame Street" whose best friend is a pink fairy named Abby Cadabby |
| 45% | CHANDLER | 8 | Friends character whose surname is a cherry |
| 44% | HELEN | 5 | With 25 Across, author whose best-known character is named Jones |
| 44% | HENRY | 5 | With 25 Across, author whose best-known character is named Jones |
| 41% | KIRK | 4 | Well known TV character whose middle name is Tiberius |
| 40% | RICKRIORDAN | 11 | Best-selling author of fantasy novels whose main characters are descended from gods: 2 wds. |
| 37% | HIS | 3 | "A boy's best friend is ___ mother" ("Psycho" quote) |
| 36% | RON | 3 | Character whose patronus is a Jack Russell terrier |
| 36% | SQUAD | 5 | "___ goals!" ("Our friends are the best!") |
| 36% | KEN | 3 | "Barbie" character whose job is "beach" |
| 36% | GEORGE | 6 | With 35-Across, Hanna-Barbera cartoon character with red hair whose best friend is a supercomputer named R.U.D.I. |
| 35% | DOG | 3 | "Man's best friend"; Snoopy was one |
| 35% | DAPHNE | 6 | Scooby-Doo character whose surname is Blake |
| 35% | ANI | 3 | Sci-fi character whose mother is Shmi |
| 35% | FRASIER | 7 | Sitcom character whose agent is Bebe Glazer |
| 35% | ELSA | 4 | "Frozen" character whose sister is named Anna |
| 35% | MOE | 3 | "The Simpsons" character whose surname is Szyslak |
| 35% | KEN | 3 | "Barbie" character whose job is just beach |