| 100% | SARS | 4 | Early-two-thousands pandemic |
| 71% | PHAT | 4 | Baby ___ (prominent fashion brand of the early two-thousands) |
| 69% | BOHO | 4 | ___-chic (hippie-inspired fashion trend of the early two-thousands) |
| 68% | REBA | 4 | McEntire who had an eponymous sitcom in the early two-thousands |
| 68% | AOL | 3 | Co. involved in a major merger of the early two-thousands |
| 66% | MOESHA | 6 | TV daughter of Frank Mitchell, in the nineties and early two-thousands |
| 66% | ONETON | 6 | Two thousand pounds |
| 66% | TON | 3 | Two thousand pounds |
| 65% | TECHBUBBLE | 10 | It burst in the early two-thousands and sent dot-com stocks tumbling |
| 65% | TONS | 4 | Two thousand pounds, plural |
| 61% | TON | 3 | About two thousand pounds |
| 59% | SARS | 4 | Outbreak in early-two-thousands news |
| 57% | THEOC | 5 | Early-two-thousands drama with the theme song “California” |
| 57% | MURSE | 5 | Man bag, in early-two-thousands slang |
| 57% | EDDAS | 5 | Two early Icelandic literary works |
| 56% | SARS | 4 | Disease in an early-two-thousands outbreak, familiarly |
| 55% | PONG | 4 | Early Atari game with two paddles |
| 55% | PONG | 4 | Early Atari game featuring two paddles |
| 55% | MST | 3 | Two hrs. earlier than N.Y. |
| 54% | THANKSINADVANCE | 15 | Two-time Best Actor winner arriving early? |
| 54% | BIPLANE | 7 | Early aircraft with two pairs of wings |
| 51% | PIMPED | 6 | Souped up, as one’s ride, in early-two-thousands slang |
| 50% | ADAMS | 5 | Last name of two early US presidents |
| 49% | ETD | 3 | What you might arrive two hrs. early for |
| 48% | NASCARDADS | 10 | Largely white and rural set of voters, in early-two-thousands political analysis |
| 47% | ONTARIO | 7 | Province with two hundred and fifty thousand freshwater lakes |
| 46% | HOMESTAR | 8 | ___ Runner (early-two-thousands animated Web series) |
| 45% | ASDIC | 5 | Early form of sonar developed by the British between the two World Wars |
| 44% | MEME | 4 | Image with two lines of Impact font, in the early days |
| 44% | TBD | 3 | Like the two Super Bowl teams in early January, for short |