| 100% | DRUNKHISTORY | 12 | Educational series on Comedy Central: 2 wds. |
| 82% | SOUTHPARK | 9 | Animated series on Comedy Central: 2 wds. |
| 66% | BROADCITY | 9 | Recently ended sitcom on Comedy Central: 2 wds. |
| 58% | SOUTHPARK | 9 | Comedy Central animated series that wrapped its 25th season in 2022: 2 wds. |
| 57% | JUSTINBIEBER | 12 | 21-year-old pop star who was roasted on Comedy Central on March 30: 2 wds. |
| 56% | SOUTHPARK | 9 | Animated Comedy Central series set in a small town in Colorado: 2 wds. |
| 55% | BOBSAGET | 8 | "Fuller House" actor who was a roastee on Comedy Central Roast with John Stamos as the roast master: 2 wds. |
| 53% | CHARLIESHEEN | 12 | "Two and a Half Men" actor who was a roastee on Comedy Central Roast with Seth MacFarlane as the roast master: 2 wds. |
| 50% | IAM | 3 | "___ Cait" (documentary series on E!): 2 wds. |
| 48% | THEDAILYSHOW | 12 | Comedy Central news satire series that debuted in 1996 (3 wds.) |
| 47% | MAGICCITY | 9 | Mob drama series on Starz, 2012-2013: 2 wds. |
| 47% | ROBOTCHICKEN | 12 | Stop-motion sketch comedy series on Adult Swim featuring a cyborg rooster: 2 wds. |
| 47% | BROADCITY | 9 | Comedy Central sitcom that starred Ilana Glazer and Abbi Jacobson: 2 wds. |
| 47% | BENSTEIN | 8 | "Win ___'s Money" (former Comedy Central game show): 2 wds. |
| 46% | TWINPEAKS | 9 | Series on which Kyle MacLachlan plays FBI Special Agent Dale Cooper: 2 wds. |
| 45% | FASHIONPOLICE | 13 | E! reality series on which judges discuss celebrities' clothing choices: 2 wds. |
| 45% | GOODOMENS | 9 | Amazon series on which 31-Across plays the demon Crowley: 2 wds. |
| 45% | BIGLOVE | 7 | HBO series on which Bill Paxton (1955-2017) played a polygamist: 2 wds. |
| 45% | POKERFACE | 9 | Natasha Lyonne murder mystery series on Peacock created by 39-Across: 2 wds. |
| 45% | NANCYDREW | 9 | Teen detective series on the CW that ended in August 2023: 2 wds. |
| 44% | THESTAIRCASE | 12 | Documentary series on Sundance TV about the murder trial of Michael Peterson: 2 wds. |
| 44% | PARTYDOWN | 9 | Comedy series about caterers on Starz, 2009-2010: 2 wds. |
| 43% | CHARLIESHEEN | 12 | "Anger Management" star who was the honoree of a 2011 Comedy Central roast: 2 wds. |
| 43% | DONALDTRUMP | 11 | "The Apprentice" host who was the honoree of a 2011 Comedy Central roast: 2 wds. |
| 43% | SOUTHPARK | 9 | Emmy-winning animated Comedy Central sitcom created by Trey Parker and Matt Stone: 2 wds. |
| 43% | FAWLTYTOWERS | 12 | 1975-1979 British series on which John Cleese's character owns a hotel: 2 wds. |
| 43% | GILMOREGIRLS | 12 | 2000-2007 American series on which Lauren Graham's character owns an inn: 2 wds. |
| 43% | SCHITTSCREEK | 12 | 2015-2020 Canadian series on which Eugene Levy's character owns a motel: 2 wds. |
| 43% | SHARKTANK | 9 | Entrepreneurial reality series on ABC with a fierce ocean menace in the title: 2 wds. |
| 43% | JAMESFRANCO | 11 | "The Interview" star who was the subject of a Comedy Central Roast in 2013: 2 wds. |