| 100% | ESME | 4 | Edward's adoptive mother in 18-Across |
| 73% | ESME | 4 | Edward's adoptive mother in "Twilight" |
| 73% | ESME | 4 | Edward's adoptive mother in ''Twilight'' |
| 71% | ESME | 4 | Edward's adoptive mother in the "Twilight" series |
| 67% | ESME | 4 | Edward’s adoptive mother, in “Twilight” |
| 47% | DIANEKEATON | 11 | "Annie Hall" actress who voiced the title character's mother in 18-Across: 2 wds. |
| 43% | MAGGIE | 6 | With 34-Across, "Psych" actress who plays the mother in 18-Across |
| 42% | EMMETT | 6 | Adoptive brother of Edward in "Twilight" |
| 42% | CAPTAIN | 7 | 18-Across's highest rank in the Navy |
| 42% | MRSCRATCHIT | 11 | Tiny Tim's mother in 38-Across |
| 41% | TRAVISBICKLE | 12 | 18-Across's character in "Taxi Driver": 2 wds. |
| 41% | VAL | 3 | Actor Kilmer who played the villain in 18-Across's film "MacGruber" |
| 40% | SARAHPALIN | 10 | 18-Across's presidential running mate in 2008: 2 wds. |
| 40% | THEBLUESTEYE | 12 | 18-Across's first novel, published in 1970: 3 wds. |
| 40% | KALA | 4 | Tarzan's adoptive mother |
| 40% | CORPUSCHRISTI | 13 | City in 18-Across |
| 40% | CAGER | 5 | Player in 18-Across |
| 39% | AUNTMAY | 7 | Peter Parker's adoptive mother |
| 39% | KENT | 4 | Martha ___ (Superman's adoptive mother) |
| 39% | BREE | 4 | ___ Tanner (vampire in 18-Across) |
| 39% | SAM | 3 | ___ Uley (werewolf in 18-Across) |
| 39% | ESSE | 4 | Verb in 18-Across 101 |
| 39% | PITTSBURGH | 10 | ___ Steelers (NFL team founded by 18-Across' mother's family) |
| 39% | MEGS | 4 | What an 18-Across's capacity is measured in, briefly |
| 39% | APE | 3 | Tarzan's adoptive mother, e.g. |
| 38% | LILYMUNSTER | 11 | Mother in a 1960's sitcom |
| 38% | HALE | 4 | Rosalie ___ (blonde vampire in 18-Across) |
| 38% | HILLARY | 7 | Mother of 18-Across |
| 38% | MIDI | 4 | 18-Across in France |
| 38% | LACEY | 5 | 18-Across's partner in a 1980s drama about two female police detectives |