| 100% | COLLINS | 7 | Eileen, first woman to command a space shuttle |
| 88% | EILEEN | 6 | ___ Collins, first woman to command a space shuttle |
| 82% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 53% | WHITSON | 7 | Peggy ___, American astronaut who became the first woman to command the International Space Station in 2007 |
| 46% | KATHRYNBIGELOW | 14 | First woman to win a Best Director Oscar |
| 46% | ITO | 3 | First woman to land a triple axel in competition |
| 45% | LISALESLIE | 10 | First woman to dunk in a WNBA game: 2 wds. |
| 45% | EILEEN | 6 | First woman Space Shuttle pilot Collins |
| 44% | ITO | 3 | First woman to land a triple axel in a major competition |
| 44% | RETTON | 6 | First woman to appear on the front of a Wheaties box |
| 44% | EVADE | 5 | Avoid first woman to have a key |
| 44% | IDALUPINO | 9 | First woman to direct a film noir (1953's "The Hitch-Hiker") |
| 44% | SARAHTHOMAS | 11 | First woman to work as a full-time NFL official (2 wds.) |
| 43% | CARDIB | 6 | First woman to win a Grammy for Best Rap Album as a solo artist |
| 43% | LESLEYVISSER | 12 | First woman to report from the sidelines for a Super Bowl game (2 wds.) |
| 43% | ANN | 3 | ___ Compton, first woman to cover the White House for a TV network |
| 42% | SVETLANA | 8 | __ Savitskaya, first woman to perform a spacewalk |
| 42% | UTA | 3 | ___ Pippig, first woman to win the Boston Marathon three times in a row |
| 42% | OTTO | 4 | Kristin ___, first woman to win six gold medals at a single Olympic games |
| 42% | EILEEN | 6 | Collins who was the first woman Space Shuttle commander |
| 42% | GALILEO | 7 | First person to use a telescope to study space |
| 42% | FDR | 3 | First prez to appoint a woman to the cabinet |
| 42% | BLACKWELL | 9 | Elizabeth __, first woman in US to become a doctor |
| 42% | EDITH | 5 | Wharton, the first woman to win a Pulitzer |
| 41% | CARDIB | 6 | First woman to win a Grammy for Best Rap Album as a solo artist (2 wds.) |
| 41% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 41% | OTTO | 4 | Swimmer Kristin ___, the first woman to win six gold medals at a single Olympics |
| 41% | EILEENCOLLINS | 13 | First female commander of a space shuttle, Columbia in 1999: 2 wds. |
| 41% | ATLANTIS | 8 | Name of the last Space Shuttle to complete a mission |
| 41% | TELSTAR | 7 | First satellite to transmit a phone call through space, 1962 |