| 100% | BISMUTH | 7 | Element with a unique last letter |
| 92% | COBALT | 6 | One of only four elements with a unique last letter |
| 52% | EMERGENC | 8 | Vitamin brand with a hyphen between its last two letters |
| 50% | TIN | 3 | Only element with a three-letter name |
| 50% | TIN | 3 | Only chemical element with a three-letter name |
| 49% | TIN | 3 | The only chemical element with a three-letter name |
| 47% | URANIUM | 7 | Element with a 235 isotope |
| 46% | NEON | 4 | Element with a museum in Las Vegas |
| 45% | AUTEUR | 6 | Filmmaker with a unique style |
| 45% | BOTTLENOSE | 10 | Dolphin with a unique beak |
| 45% | ZEBRA | 5 | Animal with a unique striped coat |
| 45% | DALI | 4 | Artist Salvador with a unique mustache |
| 45% | NOSE | 4 | Cat part with a unique print |
| 45% | DALI | 4 | Spanish artist with a unique mustache |
| 45% | BONN | 4 | German city with a double letter |
| 45% | AETNA | 5 | Insurance name with a silent letter |
| 45% | GNU | 3 | African animal with a silent letter |
| 44% | MALLSANTA | 9 | Seasonal worker with a unique dress code |
| 43% | END | 3 | With 72-Across, evasive strategy ... and a hint to the last several letters of the four longest Across answers |
| 43% | LACROSSE | 8 | Field sport played with a unique netted stick |
| 43% | ELVIS | 5 | This Costello plays guitar with a unique voice |
| 43% | PRESUME | 7 | Curriculum vitae with a cover letter? |
| 43% | ACE | 3 | Card with a letter |
| 43% | YODA | 4 | Green "Star Wars" character with a unique speech pattern |
| 42% | ZULU | 4 | Last letter of a pilot's alphabet |
| 42% | ZED | 3 | Last letter in a British alphabet book |
| 42% | SLIT | 4 | Open with a letter opener |
| 42% | ENC | 3 | Insertion with a letter (Abbr.) |
| 42% | KNEE | 4 | Joint with a silent letter |
| 42% | SLITS | 5 | Opens with a letter opener |