| 100% | QUARKS | 6 | Elementary particles with types: up, down, strange |
| 48% | DOWNQUARK | 9 | Elementary particle with an "up" counterpart |
| 45% | KAONS | 5 | Particles consisting of a strange quark and an up or down antiquark |
| 43% | QUARK | 5 | Elementary particle with six "flavors" |
| 41% | NEUTRINO | 8 | Elementary particle with no charge, proved in 1956 |
| 40% | QUARK | 5 | Particle that comes in six "flavors" — up, down, top, bottom, charm and strange |
| 38% | ELECTRON | 8 | Stable elementary particle with a negative charge present in all atoms |
| 36% | NEUTRON | 7 | Uncharged elementary particle with a mass nearly equal to that of the proton |
| 36% | RADIAL | 6 | With 58 Down, type of auto wheel |
| 36% | PIANO | 5 | With 5 Down, type of orchestral work |
| 36% | LET | 3 | Word with up or down |
| 36% | DRESS | 5 | Word with down or up |
| 35% | HADRON | 6 | Type of subatomic particle made up of quarks |
| 35% | LET | 3 | Word with up, out or down |
| 35% | SET | 3 | Word with down, up or back |
| 35% | TOWN | 4 | Word with up, mid or down |
| 34% | SAIDAPRAYER | 11 | Spoke up with one's head down? |
| 34% | SHUT | 4 | Word with in or up or down |
| 34% | SINE | 4 | Curve with lots of ups and downs |
| 34% | PROTONS | 7 | Particles composed of two up quarks and one down quark |
| 34% | MURPHY | 6 | Type of bed that can be folded up or down |
| 34% | LADDER | 6 | Equipment with rungs for climbing up or down |
| 34% | CAROUSEL | 8 | Carnival ride with horses going up and down |
| 34% | HEMLINE | 7 | It moves up and down with the fashion |
| 34% | DOW | 3 | It has its ups and downs, with "the" |
| 34% | LADDERS | 7 | Chutes and __, board game with ups and downs |
| 34% | POSITRON | 8 | Elementary particle of antimatter with the same mass as an electron, but a positive charge |
| 33% | ELO | 3 | Don't bring this orchestra down with Strange Magic |
| 33% | LAP | 3 | Down, with "up"? |
| 32% | LIE | 3 | "If you ___ down with dogs, you get up with fleas" |