| 100% | DEGENERES | 9 | Ellen who had a 1994-1998 sitcom and is now a daytime talk show host |
| 54% | ROSIEODONNELL | 13 | American TV presenter and activist who has hosted several daytime television talk shows and was a moderator on "The View": 2 wds. |
| 52% | MARIEOSMOND | 11 | Singer and talk show host who has been a spokesperson for Nutrisystem: 2 wds. |
| 49% | ELLENDEGENERES | 14 | Daytime talk show host who is a vegan: 2 wds. |
| 45% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 44% | JENNIFERHUDSON | 14 | "Dreamgirls" star who has hosted a daytime television talk show since 2022 (2 wds.) |
| 43% | KELLYCLARKSON | 13 | "American Idol" winner who has hosted a daytime television talk show since 2019 (2 wds.) |
| 43% | DREWBARRYMORE | 13 | "The Wedding Singer" actress who has hosted a daytime television talk show since 2020 (2 wds.) |
| 42% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 41% | SHERRI | 6 | Shepherd who hosts a namesake daytime talk show |
| 41% | PHILDONAHUE | 11 | Pioneering daytime talk-show host who was a 2024 recipient of the Medal of Freedom: 2 wds. |
| 39% | TAVISSMILEY | 11 | PBS talk show host who formerly had a show on NPR: 2 wds. |
| 39% | JERRY | 5 | ___ Seinfeld, comedian and show host who is a New Yorker |
| 38% | RISEANDSHINE | 12 | 43-Across novel about a morning talk show host who is fired because of an on-air gaffe (3 wds.) |
| 38% | KELLIEPICKLER | 13 | Former "American Idol" contestant who's hosting a new daytime talk show with Ben Aaron: 2 wds. |
| 37% | ROSIEODONNELL | 13 | Host of a self-titled talk show who hosted the 1999 and 2000 Grammy ceremonies: 2 wds. |
| 37% | JIMMYKIMMEL | 11 | Late-night talk show host who hosts the prime-time game show "Who Wants to Be a Millionaire": 2 wds. |
| 36% | THELATESHOW | 11 | Previously hosted by David Letterman, and now starring Stephen Colbert, CBS talk-show that was a fierce competitor of 40-Across: 3 wds. |
| 36% | DEGENERES | 9 | Talk show host and comedian Ellen |
| 36% | EVE | 3 | Rapper and actress Cooper, who currently is a host of "The Talk" on CBS |
| 36% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 35% | OPRAH | 5 | Talk host who had a satellite radio channel |
| 35% | ROLONDA | 7 | Watts who hosted a 1990s talk show |
| 35% | ARSENIO | 7 | Hall who hosted a 1990s talk show |
| 35% | IDRISELBA | 9 | Actor who was Stringer in The Wire and is now a DJ |
| 35% | RIPA | 4 | Talk show host who was once on "All My Children" |
| 35% | ARSENIOHALL | 11 | Talk show host who won a season of "Celebrity Apprentice" |
| 34% | GEORGELOPEZ | 11 | Talk show host who plays a teacher in "Spare Parts": 2 wds. |
| 34% | DIPLO | 5 | DJ who had a hit with Where Are Ü Now in 2015 |
| 34% | DEGENERES | 9 | Ellen __, sitcom star and TV chat show host |