| 100% | SOUTHPARK | 9 | Emmy-winning animated Comedy Central sitcom created by Trey Parker and Matt Stone: 2 wds. |
| 57% | PARK | 4 | "South ___," popular animated sitcom created by Trey Parker and Matt Stone |
| 49% | BOOKOF | 6 | "The ___" (with 35-Across, satirical Broadway musical created by Trey Parker, Robert Lopez, and Matt Stone: 2 wds. |
| 46% | SOUTHPARK | 9 | Animated series starring Trey Parker and Matt Stone that's named for a fictional town in Colorado: 2 wds. |
| 36% | SCHITTSCREEK | 12 | Canadian sitcom created by 26-Across and his son Daniel that won a record seven Emmys in 2020 (2 wds.) |
| 35% | BROADCITY | 9 | Comedy Central sitcom that starred Ilana Glazer and Abbi Jacobson: 2 wds. |
| 35% | THEDAILYSHOW | 12 | Satirical Comedy Central program created by Madeleine Smithberg and Lizz Winstead: 3 wds. |
| 34% | DALE | 4 | "Chip 'n ___: Rescue Rangers," American animated comedy series created by Tad Stones and Alan Zaslove |
| 31% | SUPERFUNNIGHT | 13 | ABC sitcom created by and starring 18-Across: 3 wds. |
| 30% | MONSTERSINC | 11 | 2001 animated comedy starring John Goodman and Billy Crystal with music by 33-Across (2 wds.) |
| 30% | HALFMEN | 7 | "Two and a ___," sitcom created by Chuck Lorre and Lee Aronsohn that aired on CBS: 2 wds. |
| 29% | RAVINGMAD | 9 | "Stark ___" American sitcom created by Steven Levitan, which stars Neil Patrick Harris: 2 wds. |
| 29% | MODERNFAMILY | 12 | Sitcom that has won the Emmy for Oustanding Comedy Series five years running: 2 wds. |
| 29% | SOUTHPARK | 9 | Comedy Central animated series that wrapped its 25th season in 2022: 2 wds. |
| 29% | SOUTHPARK | 9 | Animated Comedy Central series set in a small town in Colorado: 2 wds. |
| 28% | SOUTHPARK | 9 | Animated series on Comedy Central: 2 wds. |
| 28% | SQUIDGAME | 9 | Netflix series created by Hwang Dong-hyuk that won an Emmy Award for Outstanding Directing for a Drama Series in 2022 (2 wds.) |
| 28% | FUTURAMA | 8 | Popular animated sitcom created by Matt Groening about Earth in the year 3000 |
| 27% | FAMILYGUY | 9 | Fox animated series created by Seth MacFarlane: 2 wds. |
| 26% | BROADCITY | 9 | Recently ended sitcom on Comedy Central: 2 wds. |
| 26% | DESPICABLEME | 12 | Animated comedy film released in 2010 in which the title refers to the main character, Gru and his adopted daughters: 2 wds. |
| 26% | FREAKDANCE | 10 | 2011 comedy starring Amy Poehler and Matt Besser: 2 wds. |
| 26% | BROWN | 5 | "Murphy ___," TV sitcom that won the Emmy Award for Outstanding Comedy Series in 1990 and 1992 |
| 26% | HERCULEPOIROT | 13 | Fictional Belgian detective created by Agatha Christie who is also one of the most famous and long-running characters: 2 wds. |
| 25% | JESSESTONE | 10 | Fictional detective created by novelist 33-Across and played by actor 43-Across (2 wds.) |
| 25% | SEALTEAM | 8 | CBS military drama created by Benjamin Cavell and starring David Boreanaz: 2 wds. |
| 25% | BENSTEIN | 8 | "Win ___'s Money" (former Comedy Central game show): 2 wds. |
| 25% | THEMARVELOUS | 12 | "___ Mrs. Maisel," Amazon Prime's Emmy-winning series created by Amy Sherman-Palladino: 2 wds. |
| 25% | CURB | 4 | "___ Your Enthusiasm," semi-autobiographical sitcom created by and starring Larry David |
| 24% | WHENTHEYSEEUS | 13 | Emmy-nominated Netflix miniseries created by Ava DuVernay and starring 15-Across and 49-Across (4 wds.) |