| 100% | SILENTE | 7 | End of life as we know it? |
| 59% | REM | 3 | "It's the End of the World as We Know It (And I Feel Fine)" band |
| 54% | IRAN | 4 | Persia as we know it today |
| 52% | KNOW | 4 | "It's the End of the World as We ___ It" (R.E.M. song) |
| 51% | END | 3 | "It's the ___ of the world as we know it" |
| 48% | END | 3 | "Its the ___ of the World as We Know It (And I Feel Fine)" (R.E.M. song) |
| 47% | NUB | 3 | Pencil at the end of its life |
| 46% | MICHAELSTIPE | 12 | Singer who came up with "It's the End of the World as We Know It (And I Feel Fine)" in his sleep: 2 wds. |
| 46% | ALABAMA | 7 | US state known as Heart of Dixie |
| 44% | SILENTE | 7 | It comes at the end of life |
| 43% | MISSISSIPPIRIVER | 16 | It was known by the Algonquin as the "Father of Waters" |
| 43% | DEATH | 5 | End of life |
| 43% | DEATH | 5 | Ending of life |
| 43% | CLARABOW | 8 | US film actress known as The It Girl who died in 1965 |
| 43% | PAULWHITEMAN | 12 | US bandleader known as The King of Jazz who died in 1967 |
| 42% | PASSION | 7 | The final stage of Jesus' life is known as the __ |
| 42% | ASWE | 4 | “It’s the end of the world ___ know it”: R.E.M. |
| 42% | SALVIA | 6 | Plant known as "seer's sage" because of its hallucinatory effect |
| 42% | OPORTO | 6 | City north of Lisbon, as it's sometimes known |
| 41% | END | 3 | R.E.M.'s "It's the ___ of the World as We Know It" |
| 41% | ASWE | 4 | "It's the End of the World ___ Know It" (R.E.M. song) |
| 41% | IGUANA | 6 | In the Caribbean it's known as "the chicken of the trees" |
| 41% | ABALONE | 7 | The iridescent coating of its shell is known as mother-of-pearl |
| 41% | DOWNTOWN | 8 | Area known as the main part of a city in the US |
| 41% | YOUNGMAN | 8 | Henny —, London-born US comedian known as King of the One-Liners |
| 41% | DEATH | 5 | Permanent end of life |
| 41% | BOW | 3 | Clara —, US film actress known as The It Girl who died in 1965 |
| 40% | TRITONE | 7 | Interval known as "the devil in music" on account of its unsettling sound |
| 40% | EPCOT | 5 | Experimental Prototype Community of Tomorrow, as it's better known |
| 40% | EASE | 4 | "As we live a life of ___" ("Yellow Submarine" lyric) |