| 100% | VINCE | 5 | Environmental journalist Gaia ___ who was the first woman to win the Royal Society Winton Prize for Science Books |
| 54% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |
| 53% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 49% | JEN | 3 | Cartoonist Sorensen who was the first woman to win the Herblock Prize |
| 49% | ZAHA | 4 | Hadid who was the first woman to win the Pritzker Architecture Prize |
| 49% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 47% | ANNE | 4 | Sci-fi writer McCaffrey, who was the first woman to win a Hugo for fiction |
| 46% | JESMYNWARD | 10 | Mississippi novelist who is the only woman to win the National Book Award for Fiction twice (2 wds.) |
| 45% | JANEADDAMS | 10 | Social worker who was the first American woman to win the Nobel Peace Prize |
| 45% | CAROLEKING | 10 | "You've Got a Friend" singer/pianist who was the first woman to win a Grammy for Song of the Year (2 wds.) |
| 44% | CURIE | 5 | Last name of the first woman to win the Nobel Prize and who is credited with the theory of radioactivity |
| 43% | ISABELWILKERSON | 15 | "Caste" author who was the first Black woman to win the Pulitzer Prize in journalism |
| 43% | COURIC | 6 | Journalist who was the first woman to guest-host "Jeopardy!" |
| 42% | KATIECOURIC | 11 | Journalist who was the first woman to guest-host "Jeopardy!" (2 wds.) |
| 42% | TONIMORRISON | 12 | "Beloved" author who died August 5, and who was the first African-American woman to win a Nobel Prize: 2 wds. |
| 42% | MARGARETCOURT | 13 | Australian tennis player who was the first woman to win the Grand Slam in the Open Era: 2 wds. |
| 42% | MARIE | 5 | Curie who was the first person to win two Nobel Prizes |
| 42% | TENZINGYATSO | 12 | 14th Dalai Lama who was the first Tibetan to win the Nobel Peace Prize: 2 wds. |
| 42% | MOTHERTERESA | 12 | Albanian-Indian nun who was the first Asian woman (She adopted Indian citizenship) to win the Nobel Peace Prize: 2 wds. |
| 41% | MUHAMMADYUNUS | 13 | Social entrepreneur and economist who was the first Bangladeshi to win the Nobel Peace Prize: 2 wds. |
| 41% | LUISE | 5 | Rainer who was the first person to win two Academy Awards for acting |
| 40% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 40% | CURIE | 5 | Marie who is the only person to win a Nobel Prize in two different science fields |
| 40% | SING | 4 | "Of Thee I ___," Broadway musical that was the first musical to win the Pulitzer Prize for Drama |
| 40% | CORI | 4 | Gerty Theresa ___, biochemist who was the first woman to be awarded the Nobel Prize in Physiology or Medicine |
| 40% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize for Literature (3 wds.) |
| 39% | JESMYNWARD | 10 | In 2017, she became the first woman to win two National Book Awards for fiction |
| 39% | TONIMORRISON | 12 | First African-American woman to win the Nobel Prize for Literature (2 wds.) |
| 39% | RONDA | 5 | Rousey who was the first American woman to win an Olympic judo medal |
| 38% | SAUDIS | 6 | Women who were legally permitted to drive for the first time in 2018 |