| 100% | DEADTHING | 9 | Every __; first novel in Charlie Parker series |
| 51% | THEBLACKECHO | 12 | First novel in Michael Connelly's Harry Bosch series (3 wds.) |
| 51% | INHERITANCE | 11 | First novel in 39-Across's "The Lost Bride" romance series |
| 51% | RABBITRUN | 9 | First in a John Updike novel series |
| 49% | THEAWAKENING | 12 | First novel in 39-Across's "The Dragon Heart Legacy" fantasy series (2 wds.) |
| 48% | ANGELS | 6 | __ & Demons, first novel in Robert Langdon series |
| 45% | TWILIGHT | 8 | First book in a series of vampire novels by Stephenie Meyer |
| 43% | WOLF | 4 | "___ Hall" (first novel in Hilary Mantel's Thomas Cromwell series) |
| 43% | DARKOFTHEMOON | 13 | First book in a series of novels by John Sandford featuring 46-Across (4 wds.) |
| 42% | ECHO | 4 | "The Black ___" (first novel in Michael Connelly's Harry Bosch series) |
| 42% | CAMEL | 5 | "The ___ Club" (first novel in a David Baldacci political thriller series) |
| 42% | OPIONEERS | 9 | First novel in Cather's "prairie trilogy" |
| 42% | AIS | 3 | & 13D 1982 novel by Sue Grafton; first in the Kinsey Millhone alphabet mystery series |
| 42% | BONE | 4 | "The ___ Collector" (first novel in Jeffery Deaver's "Lincoln Rhyme" crime series) |
| 41% | ERAGON | 6 | First novel in Christopher Paolini's Inheritance Cycle |
| 41% | OPIONEERS | 9 | First novel in Cather's "Great Plains" trilogy |
| 41% | MEET | 4 | "___ the Austins" (first novel in Madeleine L'Engle's Austin Family Chronicles series) |
| 41% | MONEY | 5 | "One for the ___" (first novel in the Stephanie Plum series by Janet Evanovich) |
| 41% | DEAD | 4 | "___ Until Dark" (first novel in the "Sookie Stackhouse" vampire series by Charlaine Harris) |
| 41% | CROOK | 5 | "By Book or by ___" (first novel in Eva Gates' "Lighthouse Library" mystery series) |
| 41% | OPIONEERS | 9 | First novel in Willa Cather's Great Plains trilogy |
| 41% | AWAY | 4 | Like the winning team in every World Series game, for the first time ever (October, 2019) |
| 40% | CROOK | 5 | "By Book or by ___" (first novel in Eva Gates's Lighthouse Library mystery series) |
| 40% | TIME | 4 | "Only ___ Will Tell," 2011 novel by Jeffrey Archer which is the first in the "Clifton Chronicles" series |
| 40% | REDDRAGON | 9 | The first novel in the Hannibal Lecter saga |
| 40% | CLAN | 4 | "The ___ of the Cave Bear" (first novel in Jean Auel's "Earth's Children" series) |
| 40% | ARM | 3 | "The ___ of the Starfish" (first novel in Madeleine L'Engle's O'Keefe Family series) |
| 40% | EYE | 3 | "The ___ of the World" (first novel in Robert Jordan's "The Wheel of Time" series) |
| 39% | OPIONEERS | 9 | First novel in 29-Across's Great Plains trilogy (2 wds.) |