| 100% | ROOTOUT | 7 | Expose and destroy |
| 63% | ROOTOUT | 7 | Find and destroy |
| 63% | RANSACK | 7 | Plunder and destroy |
| 63% | BLITZED | 7 | Overwhelmed and destroyed |
| 58% | ROOTOUT | 7 | Expose and eliminate, as corruption |
| 56% | RANSACK | 7 | Search and destroy, perhaps |
| 53% | DEMOLISH | 8 | To damage and destroy beyond repair |
| 50% | VESUVIUS | 8 | Volcano that erupted and destroyed Pompeii in AD79 |
| 49% | WINDSWEPT | 9 | Exposed to the elements and looking bedraggled |
| 47% | RUSTY | 5 | Metal exposed to oxygen and water |
| 47% | GOMORRAH | 8 | Biblical cities God destroyed, Sodom and __ |
| 47% | SODOM | 5 | City destroyed by fire and brimstone |
| 46% | AMERICA | 7 | Down and Out in __, expose on Reaganomics |
| 46% | BLOWSTHEWHISTLE | 15 | Exposes wrongdoing, and what each starred answer frequently does |
| 46% | SODOM | 5 | City God destroyed with fire and brimstone |
| 46% | SODOM | 5 | Biblical city destroyed by fire and brimstone |
| 46% | CODLING | 7 | __ moth, pest that destroys apples and pears |
| 46% | LOCUST | 6 | Plague insect that destroys crops and fields |
| 45% | DOOM | 4 | Mount ___, volcano in Mordor where the One Ring was forged and destroyed |
| 45% | RING | 4 | What Smeagol desires, and Frodo looks to destroy |
| 45% | COEL | 4 | “I May Destroy You” creator and star Michaela |
| 44% | MIDRIFF | 7 | Area between chest and waist exposed in summer |
| 44% | GUMLINE | 7 | Boundary of flesh and exposed part of tooth |
| 44% | SCIPIO | 6 | — Aemilianus, Roman commander who besieged and destroyed Carthage in the Third Punic War |
| 43% | MICHAELA | 8 | Coel, writer and star of I May Destroy You |
| 43% | CRAFTSMAN | 9 | Home with a low-pitched roof and exposed beams |
| 43% | SACK | 4 | To pillage and destroy a place, or a way to "plunder" (rhymes with "back") |
| 42% | MICHAELACOEL | 12 | Creator and star of “I May Destroy You” (June, 2020) |
| 40% | PIPERALPHA | 10 | North Sea oil rig that exploded and was destroyed in 1988 |
| 39% | SODOM | 5 | City destroyed by "brimstone and fire from the Lord out of heaven" |