| 100% | TGIF | 4 | Expression of relief at the start of the weekend: Abbr. |
| 58% | TGIF | 4 | Expression announcing the arrival of the weekend: Abbr. |
| 57% | TGIF | 4 | Expression of words said in relief by every office-goer when the weekend rolls around: Abbr. |
| 57% | ATTN | 4 | Abbr. at the start of a memo |
| 56% | ASST | 4 | Abbr. at the start of some job titles |
| 56% | JAN | 3 | Abbr. at the start of a day planner |
| 56% | ETC | 3 | Abbr. rarely seen at the start of a sentence |
| 55% | FYI | 3 | Abbr. that's at the start of many forwarded emails |
| 53% | USS | 3 | Letters at the start of an American navy vessel's name: Abbr. |
| 53% | TGIF | 4 | Cry of relief as the weekend approaches: Abbr. |
| 50% | AFEWCHOICEWORDS | 15 | Euphemism for rude expressions, and what can be found at the starts of 17-, 26-, and 48-Across |
| 48% | CREATIONSTORY | 13 | Narrative at the start of the Bible |
| 48% | SATURDAY | 8 | Start of the weekend, often |
| 47% | PLOP | 4 | Sound at the start of the Alka-Seltzer jingle |
| 47% | SALERNO | 7 | Italian city at the start of the Amalfi coast |
| 47% | JAN | 3 | Start of the year: Abbr. |
| 47% | TIED | 4 | Like the score at the start of the 10th inning |
| 47% | TOSEA | 5 | Words repeated at the start of the "Sailor's Song" |
| 47% | TEN | 3 | Number of pins at the start of a bowling frame |
| 47% | CUB | 3 | Simba, at the start of "The Lion King" |
| 47% | TGIF | 4 | Cry at the end of the workweek: Abbr. |
| 47% | TGIF | 4 | Comment at the end of the workweek: Abbr. |
| 46% | AREACODES | 9 | Digits at the start of digits |
| 46% | TIE | 3 | Situation at the start of overtime |
| 46% | SIXTEEN | 7 | Number of pawns at the start of a game of chess |
| 46% | OBESE | 5 | Like a "Biggest Loser" contestant at the start of the season |
| 46% | LIFE | 4 | One of three at the start of a Pac-Man game |
| 46% | ANAPHORA | 8 | Repetition of words at the starts of successive phrases, in rhetoric |
| 46% | TGIF | 4 | Jubilant cry at the end of the workweek: Abbr. |
| 46% | TAKEOFF | 7 | At the start of a flight, you prepare for __ |