| 100% | EBOND | 5 | F.D.R. purchased the first one |
| 61% | FLAPPER | 7 | F. Scott Fitzgerald called Zelda the first American one |
| 46% | DIME | 4 | The Roosevelt one was designed by John R. Sinnock |
| 44% | DRUG | 4 | The "D" of F.D.A. |
| 43% | EMAIL | 5 | The first one was sent in 1971 |
| 43% | APOSTLE | 7 | One of the first disciples |
| 42% | OBOE | 4 | One throwing out the first pitch? |
| 42% | AOL | 3 | One of the first Internet service providers |
| 42% | CREE | 4 | One of the First Nations of Canada |
| 41% | GMOS | 4 | They're regulated by the F.D.A. |
| 41% | PIE | 3 | The first one to be filmed hitting someone in the face was in the 1909 film Mr. Flip |
| 41% | WPA | 3 | F.D.R. jobs program |
| 41% | BOSN | 4 | One under the first mate, for short |
| 41% | BIRTH | 5 | The first event in one's life |
| 41% | HST | 3 | President between F.D.R. and D.D.E. |
| 40% | JUUL | 4 | Vaping brand that was targeted by the F.D.A. |
| 40% | REST | 4 | The first "R" in R&R |
| 40% | PLANE | 5 | Commercial aircraft; the first one flew in 1903 |
| 40% | CRUSADE | 7 | Pope Urban II launched the first one in 1095 |
| 40% | WAR | 3 | The first recorded one was between Sumer and Edam |
| 40% | IDOL | 4 | Kelly Clarkson was the first American one |
| 39% | OLYMPIC | 7 | The first modern one of these games was in Greece |
| 39% | ROME | 4 | First city to reach a population of one million people, in the second century B.C. |
| 39% | HST | 3 | Prez after F.D.R. |
| 39% | EMAIL | 5 | Clinton was the first president to send one |
| 39% | DEV | 3 | The "D" of R&D: Abbr. |
| 39% | STEP | 4 | "Pierce film with fork" might be the first one |
| 39% | TOFU | 4 | Soybean product whose last letter is the first one for 53a |
| 39% | GRAPES | 6 | Vineyard fruits whose last letter is the first one for 45a |
| 39% | POLIO | 5 | Ailment suffered by F.D.R. |