| 100% | ECKO | 4 | Fashion designer Marc (and homonym of 2-Down) |
| 51% | EDNA | 4 | Fashion designer Mode of "Incredibles 2" |
| 50% | COCOCHANEL | 10 | French fashion designer and namesake of the brand that was founded in 1909 and is known for its perfume No. 5: 2 wds. |
| 47% | COCO | 4 | ___ Chanel, French fashion designer and founder of the Chanel brand |
| 46% | VERSACE | 7 | Surname of fashion designers Gianni and Donatella |
| 45% | STELLAMCCARTNEY | 15 | British fashion designer who's the daughter of Linda and Sir Paul |
| 45% | WESTWOOD | 8 | Vivienne —, fashion designer named British Designer of the Year in 1990 and 1991 |
| 45% | MARYQUANT | 9 | English fashion designer credited with the design of the miniskirt and hot pants |
| 44% | ECKO | 4 | Fashion designer Marc |
| 44% | JACOBS | 6 | Fashion designer Marc |
| 43% | MARC | 4 | First name of fashion designers Ecko and Jacobs |
| 43% | ELIE | 4 | First name of fashion designers Tahari and Saab |
| 43% | COCOCHANEL | 10 | Fashion designer associated with the item spelled out by the starts of 17-, 26- and 42-Across |
| 43% | CALVINKLEIN | 11 | US fashion designer who had early success with designer jeans and fragrances like Obsession: 2 wds. |
| 43% | RALPHLAUREN | 11 | US fashion designer known for shirts whose logo is a polo pony and rider: 2 wds. |
| 42% | GALLIANO | 8 | John —, 1987, 1994 and 1995 British Fashion Awards Designer of the Year |
| 42% | GIORGIOARMANI | 13 | Italian fashion designer whose eponymous company has "Emporio" as part of a flagship brand name: 2 wds. |
| 42% | CHRISTIANDIOR | 13 | French fashion designer whose eponymous company has "Homme" as part of a flagship brand name: 2 wds. |
| 42% | UTES | 4 | Relatives of 2 Down |
| 42% | AMITE | 5 | Antonym of 2 Down |
| 42% | LUKEBRYAN | 9 | "Strip It Down" singer and 2015 CMA Entertainer of the Year: 2 wds. |
| 41% | TOMMYHILFIGER | 13 | US fashion designer who started with preppy menswear and a red, white, and blue flag logo: 2 wds. |
| 41% | JACOBS | 6 | New York fashion designer Marc ___ |
| 41% | USA | 3 | Charter member of 2 Down |
| 41% | SHAH | 4 | Former ruler of 2 Down |
| 40% | SELENAGOMEZ | 11 | "Wizards of Waverly Place" star and singer with a fashion line at Kmart: 2 wds. |
| 40% | RAGDOLLS | 8 | 2 Down and Andy |
| 40% | ANKH | 4 | Symbol called a key of 2 Down |
| 40% | TOMFORD | 7 | Fashion designer and film director |
| 39% | BURTREYNOLDS | 12 | "Smokey and the Bandit" actor who turned down the role of Edward in 17-Across: 2 wds. |