| 100% | SORE | 4 | Feeling the effects of a long shift, say |
| 72% | ILL | 3 | Feeling the effects of a cold, say |
| 72% | AIL | 3 | Feel the effects of a cold, say |
| 71% | ACHY | 4 | Feeling the effects of a tough workout, say |
| 62% | SORE | 4 | Feeling the effects of a workout |
| 62% | ILL | 3 | Feeling the effects of a virus |
| 62% | ITCHY | 5 | Feeling the effects of a rash |
| 62% | ACHED | 5 | Felt the effects of a workout |
| 62% | ACHE | 4 | Feel the effects of a workout |
| 61% | SORE | 4 | Feeling the effects of a hard workout |
| 59% | WOOZY | 5 | Feeling the effects of anesthesia, say |
| 58% | SORE | 4 | Feeling the effects of too much exercise, say |
| 58% | ALERT | 5 | Feeling the effects of an espresso shot, say |
| 57% | SORE | 4 | Feeling the aftermath of a long day of work |
| 50% | NUMB | 4 | Feeling the effects of Novocaine |
| 50% | NUMB | 4 | Feeling the effects of Novocain |
| 49% | SAG | 3 | Feel the effect of gravity |
| 49% | DROOP | 5 | Feel the effect of gravity |
| 49% | TIRED | 5 | Feeling the effects of sleep deprivation |
| 49% | ALERT | 5 | Feeling the effects of matcha, maybe |
| 49% | SORE | 4 | Feeling the effects of leg day |
| 49% | STONED | 6 | Feeling the effects of an edible |
| 49% | ACHE | 4 | Feel the effects of strenuous exercise |
| 48% | SORE | 4 | Feeling the effects of too much exercise |
| 48% | RISINGSEALEVELS | 15 | One effect of global warming, and a hint to the five longest Down answers |
| 48% | REEL | 4 | Suffer the effects of a haymaker |
| 48% | ANTIDOTAL | 9 | Counteracting the effects of a poison |
| 47% | ITCHINTIME | 10 | Eventually feel the effects of poison ivy? |
| 47% | SEDATE | 6 | Enjoying the effects of a CBD gummy, maybe |