| 100% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 42% | NANCYDREW | 9 | Fictional girl detective who first appeared in 1930 novel The Secret of the Old Clock by Carolyn Keene |
| 36% | PERRYMASON | 10 | Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 35% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 34% | PERRY | 5 | & 25A Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |
| 33% | NELSON | 6 | Lee ___, a fictional character created by comedian Simon Brodkin who has pranked the likes of Theresa May and Kanye West |
| 33% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 33% | SEXTONBLAKE | 11 | Fictional detective who first appeared in 1893 story The Missing Millionaire by Hal Meredeth aka Harry Blyth |
| 32% | CHAN | 4 | Fictional character who first appeared in "The House Without a Key" |
| 32% | VANDERVALK | 10 | Piet —, Dutch detective created by Nicholas Freeling who first appeared in 1962 novel Love in Amsterdam |
| 31% | KATHRYNDANCE | 12 | Fictional California Bureau of Investigation special agent created by 32-Across who appears in crossover novels with 18-Across (2 wds.) |
| 31% | XENA | 4 | Character who first appeared in "Hercules: The Legendary Journeys" |
| 30% | GEORGESMILEY | 12 | Fictional spy who first appeared in "Call for the Dead" |
| 29% | KILGORETROUT | 12 | Fictional novelist who appears in several novels by 41-Across, including "Slaughterhouse-Five" and "Breakfast of Champions" (2 wds.) |
| 29% | PETERDECKER | 11 | Fictional LAPD lieutenant created by 30-Across who meets his wife, 40-Across, in the novel "The Ritual Bath" (2 wds.) |
| 29% | HERCULEPOIROT | 13 | Fictional Belgian detective created by Agatha Christie who is also one of the most famous and long-running characters: 2 wds. |
| 29% | CAMPION | 7 | Albert —, detective creation of Margery Allingham who first appeared in 1929 novel The Crime At Black Dudley |
| 29% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in 1925 novel The House Without a Key |
| 29% | RAISIN | 6 | Agatha —, fictional creation of M C Beaton who first appeared in a 1992 mystery novel |
| 28% | ABE | 3 | Animated character who first appeared in the Simpsons short "Grandpa and the Kids" |
| 28% | ABE | 3 | "Simpsons" character who first appeared in the cartoon "Grampa and the Kids" |
| 28% | YODA | 4 | Character who appeared via CGI in "Attack of the Clones" |
| 28% | WORF | 4 | Character who has appeared in the most episodes of the various "Star Trek" series |
| 28% | BILLY | 5 | Speedy British comic character who first appeared in The Beano in 1964 |
| 27% | BILL | 4 | "___ Denbrough," fictional character who is the main protagonist of Stephen King's 1986 novel "It" |
| 27% | KETCHUM | 7 | Ash ___, fictional character in Pokemon franchise who is the main protagonist of the anime series |
| 27% | BAGGINS | 7 | Frodo ___, fictional character from "The Lord of the Rings" played by Elijah Wood in the movies |