| 100% | CHAN | 4 | Fictional character who first appeared in "The House Without a Key" |
| 82% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in The House Without a Key |
| 62% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 59% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in 1925 novel The House Without a Key |
| 54% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 54% | XENA | 4 | Character who first appeared in "Hercules: The Legendary Journeys" |
| 54% | BILLY | 5 | Speedy British comic character who first appeared in The Beano in 1964 |
| 54% | ABE | 3 | "Simpsons" character who first appeared in the cartoon "Grampa and the Kids" |
| 53% | ABE | 3 | Animated character who first appeared in the Simpsons short "Grandpa and the Kids" |
| 52% | GEORGESMILEY | 12 | Fictional spy who first appeared in "Call for the Dead" |
| 50% | NANCYDREW | 9 | Fictional young female detective who first appeared in a 1930 book credited to the pen name Carolyn Keene: 2 wds. |
| 50% | HARDYBOYS | 9 | Fictional young male detectives who first appeared in a 1927 book credited to the pen name Franklin W Dixon: 2 wds. |
| 50% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 49% | YODA | 4 | "Star Wars" character who first appears in "The Empire Strikes Back" |
| 49% | SEXTONBLAKE | 11 | Fictional detective who first appeared in 1893 story The Missing Millionaire by Hal Meredeth aka Harry Blyth |
| 45% | BOBBSEYTWINS | 12 | Fictional young brother-and-sister detectives who first appeared in a 1904 book credited to the pen name Laura Lee Hope: 2 wds. |
| 45% | ART | 3 | ___ Vandelay, recurring fake "Seinfeld" character who appears as a real judge in the series finale |
| 45% | NODDY | 5 | Enid Blyton children's book character who first appeared in 1949 |
| 44% | APU | 3 | Shopkeeper who first appears in the "Simpsons" episode "The Telltale Head" |
| 44% | NANCYDREW | 9 | Fictional girl detective who first appeared in 1930 novel The Secret of the Old Clock by Carolyn Keene |
| 44% | TRIXIEBELDEN | 12 | Fictional young female detective who first appeared in a 1948 book by Julie Campbell Tatham: 2 wds. |
| 44% | DAFFY | 5 | Cartoon duck who first appeared in the 1937 short "Porky's Duck Hunt" |
| 43% | ELMO | 4 | Red Muppet who first appeared in the "Sesame Street" song "We Are All Monsters" |
| 43% | SISTER | 6 | With 29-Across, Pam Ferris character who was a midwife and nun in Nonnatus House on "Call the Midwife" |
| 42% | CHAN | 4 | "The House Without a Key" hero |
| 42% | WORF | 4 | Character who has appeared in the most episodes of the various "Star Trek" series |
| 42% | TWEETYBIRD | 10 | Cartoon canary who first appeared in 1942's A Tale of Two Kitties |
| 42% | ELMO | 4 | Character who first became prominent on "Sesame Street" in the 1980s |
| 41% | PADME | 5 | Queen who first appears in “The Phantom Menace” |