| 100% | QUAHOG | 6 | Fictional Rhode Island city that's the setting for 15-Across |
| 52% | ARLES | 5 | City that's the setting for several van Gogh paintings |
| 49% | SAVANNAH | 8 | Southern city that's the setting for "Midnight in the Garden of Good and Evil" |
| 47% | YORK | 4 | New New ___, fictional futuristic city that is the setting for "Futurama" |
| 43% | TROY | 4 | Ancient Greek city that was the setting for the Trojan War |
| 42% | ARLEN | 5 | Fictional town in Texas that is the setting for "King of the Hill" |
| 41% | FIJI | 4 | South Pacific island nation that was the setting for "Survivor" season 14 |
| 41% | BEDROCK | 7 | Fictional prehistoric town that is the setting for "The Flintstones" |
| 41% | PALAU | 5 | Micronesian island that was the setting for a season of "Survivor" |
| 41% | VIETNAM | 7 | War that's the setting for the film Apocalypse Now |
| 40% | TRALEE | 6 | City that's a near-rhyme to 15 Across |
| 40% | NOME | 4 | City that's the finish line for the Iditarod |
| 40% | IOWA | 4 | State that's the setting for "The Bridges of Madison County" |
| 40% | SEINE | 5 | River that's the setting for van Gogh's "Fishing in Spring" |
| 39% | NOLA | 4 | City that's the subject of the book Musical Gumbo, for short |
| 38% | SAVANNAH | 8 | Georgia city that's the setting of Midnight in the Garden of Good and Evil |
| 38% | DEVON | 5 | English county that's the setting for Agatha Christie's "And Then There Were None" |
| 37% | ORIENTEXPRESS | 13 | Train that's the setting for murder in a 2017 remake directed by Kenneth Branagh (2 wds.) |
| 37% | SITKA | 5 | Alaska city that's larger in area than Rhode Island or Delaware |
| 36% | NEST | 4 | ___ egg (money that's set aside for the future) |
| 36% | COMICBOOK | 9 | Setting for each of the places in 15-, 21-, and 41-Across: 2 wds. |
| 35% | ASWAN | 5 | City that includes the island of Elephantine |
| 35% | STOCKHOLM | 9 | City that presents the Nobel prize for literature |
| 35% | DAYTON | 6 | City that was home for the Wright brothers |
| 35% | EST | 3 | Clock setting for the New Year's Eve ball drop in New York City (Abbr.) |
| 35% | NAURU | 5 | Island that's the world's third-smallest country, after Vatican City and Monaco |
| 34% | TROY | 4 | Ancient city that is the setting of the "Iliad" |
| 34% | RIO | 3 | City that hosted the 2016 Olympic Games, for short |
| 34% | RIO | 3 | City that hosted the Summer Olympics after London, for short |
| 34% | RIO | 3 | City that hosted the most recent Summer Olympics, for short |