| 100% | LESTRADE | 8 | Fictional Scotland Yard inspector in stories by Arthur Conan Doyle involving Sherlock Holmes who first appeared in A Study in Scarlet |
| 39% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |
| 38% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 37% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 36% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 36% | SCANDAL | 7 | "A ___ in Bohemia," Sherlock Holmes short story by Arthur Conan Doyle |
| 33% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 33% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 33% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 32% | TRIXIEBELDEN | 12 | Fictional young female detective who first appeared in a 1948 book by Julie Campbell Tatham: 2 wds. |
| 31% | SEXTONBLAKE | 11 | Fictional detective who first appeared in 1893 story The Missing Millionaire by Hal Meredeth aka Harry Blyth |
| 30% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle, who you may associate with 20a, 33a, 42a, 9d, and 36d |
| 30% | FINAL | 5 | "The ___ Problem," Sherlock Holmes short story by Arthur Conan Doyle |
| 30% | ADLER | 5 | Irene in a short story by Sir Arthur Conan Doyle |
| 30% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 30% | PIPS | 4 | "The Five Orange ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 29% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 29% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 28% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle |
| 28% | CHAN | 4 | Fictional character who first appeared in "The House Without a Key" |
| 28% | SCARLET | 7 | A Study in __, 1887 Arthur Conan Doyle novel |
| 28% | SCARLET | 7 | A Study in __, the first Sherlock Holmes account |
| 28% | RAISIN | 6 | Agatha —, fictional creation of M C Beaton who first appeared in a 1992 mystery novel |
| 27% | FINAL | 5 | "The ___ Problem," Sherlock Holmes story that was originally intended by Arthur Conan Doyle to be his last Holmes-related work |
| 27% | NANCYDREW | 9 | Fictional young female detective who first appeared in a 1930 book credited to the pen name Carolyn Keene: 2 wds. |
| 27% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |
| 27% | HARDYBOYS | 9 | Fictional young male detectives who first appeared in a 1927 book credited to the pen name Franklin W Dixon: 2 wds. |
| 27% | IRENEADLER | 10 | Holmes character created by Arthur Conan Doyle who may be modeled after Lillie Langtry or Lola Montez |
| 27% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 26% | PASTICHE | 8 | Sherlock Holmes story not by Conan Doyle, e.g. |