| 100% | SAINTLEO | 8 | Fifth-century pope who was the first to be called "the Great" |
| 63% | LEOI | 4 | First pope to be called "the Great" |
| 63% | STLEO | 5 | First pope to be called "the Great" |
| 58% | STLEO | 5 | Fifth-century pope, the first to receive the title "the Great" |
| 58% | MELALLEN | 8 | Announcer who was the first to call DiMaggio "Joltin' Joe" |
| 54% | BASIE | 5 | Jazz great who was the first African-American man to win a Grammy |
| 53% | POPELEO | 7 | First religious leader of his title to be called "The Great" |
| 53% | ALTHEAGIBSON | 12 | Tennis great who was the first person of color to win a Wimbledon championship (2 wds.) |
| 50% | DEE | 3 | Sandra who was the first to play "Gidget" |
| 49% | NIMOY | 5 | Actor Leonard who was the first to play Spock |
| 49% | DEE | 3 | Actress Sandra who was the first to play Gidget |
| 49% | DEE | 3 | Actress Sandra who was the first to play "Gidget" |
| 49% | ALYN | 4 | Kirk ___, actor who was the first to play Superman |
| 49% | BIGMAMATHORNTON | 15 | Singer who was the first to record “Hound Dog” |
| 49% | ALEC | 4 | Baldwin who was the first to play Jack Ryan |
| 49% | PIUSII | 6 | 15th-century pontiff who was the only pope to write an autobiography |
| 49% | GLENN | 5 | John who was the first American to orbit the earth |
| 49% | HAYES | 5 | Helen who was the first actress to achieve the EGOT |
| 49% | SUTTERSMALL | 11 | Historic shopping center that was the first to be called "a gold mine for investors"? |
| 48% | ALEC | 4 | Actor Guinness who was the first to play Obi-Wan Kenobi |
| 48% | ALEX | 4 | Honnold who was the first to free-solo climb El Capitan |
| 48% | GALILEO | 7 | Astronomer who was the first to discover that the Milky Way was made up of stars |
| 48% | JEN | 3 | Cartoonist Sorensen who was the first woman to win the Herblock Prize |
| 48% | ZAHA | 4 | Hadid who was the first woman to win the Pritzker Architecture Prize |
| 48% | TOBEY | 5 | Actor Maguire who was the first to play Spider-Man in movies |
| 48% | HILLARYCLINTON | 14 | Secretary of State who was the first to visit Burma since 1955 |
| 48% | BESSEL | 6 | German astronomer who was the first to measure the distance to a star |
| 48% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |
| 48% | TEBOW | 5 | Former quarterback Tim who was the first sophomore to win the Heisman Trophy |
| 48% | RIC | 3 | Flair who was the first wrestler to complete the WCW's Triple Crown |