| 100% | MORTALKOMBAT | 12 | Fighting video game adapted into a series of films: 2 wds. |
| 64% | RESIDENTEVIL | 12 | Video game franchise made into a series of films starring Milla Jovovich (2 wds.) |
| 55% | ANGRYBIRDS | 10 | Puzzle video game adapted into two Jason Sudeikis animated films: 2 wds. |
| 55% | TOMBRAIDER | 10 | Adventure video game adapted into films starring Angelina Jolie and Alicia Vikander: 2 wds. |
| 50% | HANDMAIDSTALE | 13 | Margaret Atwood's dystopian novel, "The ___" which has been adapted into a film, an opera and a TV series: 2 wds. |
| 49% | ATWAR | 5 | Fighting a series of battles: 2 wds. |
| 48% | MORTALKOMBAT | 12 | Video game franchise made into a 1995 film starring Linden Ashby (2 wds.) |
| 47% | STREETFIGHTER | 13 | Video game franchise made into a 1994 film starring Jean-Claude Van Damme (2 wds.) |
| 47% | RESIDENTEVIL | 12 | Survival-horror video game series, or a 2002 Milla Jovovich film: 2 wds. |
| 46% | THEPRODUCERS | 12 | Mel Brooks film of 1967 adapted into a 2001 Broadway musical and 2005 movie musical: 2 wds. |
| 46% | CHERYLSTRAYED | 13 | American novelist whose memoir "Wild" was adapted into a 2014 film: 2 wds. |
| 45% | STREETFIGHTER | 13 | Combat-based video game series, or a 1994 Jean-Claude Van Damme film: 2 wds. |
| 45% | SUSANNAKAYSEN | 13 | American author whose memoir "Girl, Interrupted" was adapted into a 1999 film: 2 wds. |
| 45% | JOHNNYENGLISH | 13 | Fictional spy portrayed by Rowan Atkinson in a series of parody films: 2 wds. |
| 44% | HIGHFIDELITY | 12 | 50-Across novel that was adapted into a feature film in 2000, a Broadway musical in 2006, and a TV series in 2020 (2 wds.) |
| 44% | NEEDFORSPEED | 12 | Car-racing video game series, or a 2014 Aaron Paul film: 3 wds. |
| 43% | MAZERUNNER | 10 | James Dashner's dystopian novel, "The ___" which was adapted into a film directed by Wes Ball: 2 wds. |
| 43% | OLDMAN | 6 | *"The ___ and the Sea," 1952 novel by Ernest Hemingway that was adapted into a 1958 film: 2 wds. |
| 43% | JAYASHER | 8 | Author whose book "Thirteen Reasons Why" was adapted into a Netflix show of the same name: 2 wds. |
| 43% | NAUGHTYDOG | 10 | Video game company that created the "Uncharted" action-adventure game series, which has been adapted into a film starring Antonio Banderas, 31-Across, and 43-Across (2 wds.) |
| 41% | SOPHIESCHOICE | 13 | 1979 novel by 47-Across adapted into a film starring 30-Across (2 wds.) |
| 41% | GILLIANFLYNN | 12 | Author of "Gone Girl," a novel adapted into a film starring Rosamund Pike (2 wds.) |
| 41% | THEORIENT | 9 | "Murder on ___ Express," Agatha Christie's detective novel published in 1934, which was adapted into a film starring Kenneth Branagh in 2017: 2 wds. |
| 40% | ARKHAM | 6 | Batman: __ is a series of video games |
| 40% | SUSANNAKAYSEN | 13 | Author of "Girl, Interrupted," a memoir adapted into a film starring Winona Ryder (2 wds.) |
| 40% | RICHARDFORD | 11 | "The Sportswriter" novelist whose novel 47-Across was adapted into a film by 14-Across (2 wds.) |
| 40% | SLY | 3 | ___ Cooper (raccoon in a series of video games) |
| 40% | SIMS | 4 | Virtual people in a series of video games |
| 40% | FEVERPITCH | 10 | 50-Across memoir adapted into a British film about soccer and an American film about baseball (2 wds.) |
| 40% | RAYNE | 5 | Vampire-killing woman in a series of video games |