| 100% | PATIENTZERO | 11 | Figure often invoked in articles about the origins of outbreaks |
| 41% | CASTE | 5 | “___: The Origins of Our Discontents” (Isabel Wilkerson book about social stratification in America) |
| 38% | BIGBANGLETHEORY | 15 | Hypothesis about the origin of bracelets? |
| 37% | BIGBANGLETHEORY | 15 | Hypothesis about the origin of oversized bracelets? |
| 34% | POLARBEARS | 10 | Arctic mammals often invoked in discussions of climate change |
| 34% | ASIAN | 5 | Like the origin of the food in many fusion restaurants |
| 33% | EDEN | 4 | Origin of the Tigris and the Euphrates, in Genesis |
| 32% | IDIOM | 5 | Figure of speech like "pie in the sky" |
| 32% | ISLE | 4 | Often-uninhabited piece of land in the sea |
| 32% | HAT | 3 | Article of clothing in the Arby's logo |
| 32% | VII | 3 | Number of articles in the Constitution |
| 31% | TECH | 4 | "___-savvy" (one informed about the latest in the world of gadgets) |
| 31% | ONE | 3 | Figure in the top left of a crossword grid |
| 31% | ISLE | 4 | One of about 700 in the Bahamas |
| 31% | METALS | 6 | About 80% of the elements in the period table |
| 31% | AREAMAN | 7 | Facetious subject of many articles in The Onion |
| 31% | ALP | 3 | Part of it is often in the clouds |
| 31% | TONSILS | 7 | Masses of tissue in the throat, often removed |
| 31% | MAIN | 4 | Name of the biggest street in town, often |
| 31% | SPRAIN | 6 | Painful injury of ligament, often in the ankle |
| 31% | ELI | 3 | Figure in the Book of Samuel |
| 30% | AGE | 3 | Figure that rapidly increases for some of the characters in Old |
| 30% | HAMSTRING | 9 | Group of three muscles in the thigh; often pulled |
| 30% | MISUSED | 7 | Like the word "ironic" in place of "unfortunate," often |
| 30% | NEURON | 6 | One of about 100 billion in the human brain |
| 30% | CHURCH | 6 | One of about 400,000 in the United States |
| 30% | LOLLIPOP | 8 | Type of candy The Chordettes sang about in 1958 |
| 30% | VIRTUAL | 7 | Type of insanity Jamiroquai sung about in the 90s |
| 30% | GOSPEL | 6 | One of four books about Jesus in the Bible |
| 30% | MINIBAREXAM | 11 | Interrogation of the housekeeper about available in-room beverages? |