| 100% | SEANCONNERY | 11 | First actor to play James Bond on the big screen (2 wds.) |
| 61% | ALYN | 4 | Kirk ___, first actor to play Superman on the big screen |
| 50% | CONNERY | 7 | First actor to portray James Bond on film, Sean __ |
| 47% | ALYN | 4 | Kirk ___, first actor to play Superman on screen, 1948 |
| 45% | GROWINGPAINS | 12 | TV show that cast Leonardo DiCaprio before he got his break on the big screen: 2 wds. |
| 45% | BROSNAN | 7 | Actor Pierce who played James Bond on screen |
| 45% | SEANCONNERY | 11 | First James Bond in the movies: 2 wds. |
| 44% | MATTHEWPERRY | 12 | Actor who played Chandler Bing on the NBC sitcom "Friends," which first aired September 22, 1994 (2 wds.) |
| 43% | TIMROTH | 7 | "Pulp Fiction" actor who played Dr. Cal Lightman on the Fox series "Lie To Me": 2 wds. |
| 43% | MATTSMITH | 9 | Eleventh actor to play the lead role in 15-Across (2010-2013): 2 wds. |
| 43% | DAVIDTENNANT | 12 | Tenth actor to play the lead role in 15-Across (2005-2010): 2 wds. |
| 43% | MOORE | 5 | Roger who was the oldest actor to play James Bond |
| 43% | PETERCAPALDI | 12 | Twelfth actor to play the lead role in 15-Across, starting in 2013: 2 wds. |
| 43% | LORRE | 5 | Peter who was the first actor to play a Bond villain |
| 42% | KENNETHBRANAGH | 14 | "Murder on the Orient Express" (2017) star who is the only actor to direct himself playing Hercule Poirot (2 wds.) |
| 42% | DRNO | 4 | The first James Bond film: 2 wds. |
| 42% | DRNO | 4 | The first James Bond movie: 2 wds. |
| 42% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |
| 42% | NEILARMSTRONG | 13 | First astronaut to walk on the moon: 2 wds. |
| 42% | KENNETHBRANAGH | 14 | "Murder on the Orient Express" and 45-Across star who is the only actor to direct himself playing Hercule Poirot (2 wds.) |
| 42% | NEILARMSTRONG | 13 | First person to walk on the moon (1969): 2 wds. |
| 41% | FREDSAVAGE | 10 | Actor who played Kevin Arnold on the original 32-Across and who directed the first episode of the 2021 reboot of 32-Across (2 wds.) |
| 41% | TIMOTHYDALTON | 13 | Former James Bond portrayer who played Sir Malcolm Murray on 21-Across: 2 wds. |
| 41% | JIMPARSONS | 10 | Actor who plays Sheldon on "The Big Bang Theory" (2 wds.) |
| 41% | JOHNNYGALECKI | 13 | Actor who plays Leonard on "The Big Bang Theory" (2 wds.) |
| 41% | DRNO | 4 | First of the James Bond films: 2 wds. |
| 41% | DRNO | 4 | First of the James Bond movies: 2 wds. |
| 41% | ALBERTFINNEY | 12 | "Murder on the Orient Express" (1974) star who is the only actor to be nominated for an Oscar for playing Hercule Poirot (2 wds.) |
| 41% | RANDALLPARK | 11 | Actor who plays Louis, the dad on "Fresh Off the Boat": 2 wds. |
| 41% | FRANKIEMUNIZ | 12 | Actor who played child prodigy Malcolm on "Malcolm in the Middle": 2 wds. |