| 100% | MAEJEMISON | 10 | First African-American woman in space, aboard the space shuttle Endeavour in 1992: 2 wds. |
| 71% | ELLENOCHOA | 10 | First Hispanic woman in space, aboard the space shuttle Discovery in 1993: 2 wds. |
| 56% | MAE | 3 | ___ Jemison, American astronaut who became the first African-American woman to travel to space in 1992 |
| 55% | SALLYRIDE | 9 | First American woman in space: 2 wds. |
| 53% | JANEADDAMS | 10 | First American woman to be awarded the Nobel Peace Prize, in 1931: 2 wds. |
| 53% | VENUSWILLIAMS | 13 | First African-American woman to hold the world #1 ranking in tennis's Open era: 2 wds. |
| 52% | VENUSWILLIAMS | 13 | First African-American tennis player to be ranked #1 in women's singles during the Open Era: 2 wds. |
| 51% | FRANCESARNOLD | 13 | First American woman to win the Nobel Prize in Chemistry, in 2018: 2 wds. |
| 51% | KALPANACHAWLA | 13 | Indian American astronaut aboard the ill-fated Space Shuttle Columbia in 2003 who was on her second mission on the same shuttle: 2 wds. |
| 51% | JEMISON | 7 | Mae, first African American woman in space |
| 49% | MAE | 3 | Astronaut Jemison who was the first African-American woman in space |
| 49% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 48% | JANETJACKSON | 12 | "Rhythm Nation" R&B singer who received the 1990 MTV Video Vanguard Award, the first African American woman to do so: 2 wds. |
| 47% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 47% | SALLYRIDE | 9 | She was the first American woman in Space |
| 46% | SALLY | 5 | ___ Ride who was the first American woman in space |
| 46% | MAE | 3 | ___ Jemison (first African American woman in space) |
| 46% | RIDE | 4 | Astronaut Sally who was the first American woman in space |
| 46% | RIDE | 4 | She became the first American woman in space in 1983 |
| 45% | MISTYCOPELAND | 13 | First African-American prima ballerina for the American Ballet Theater: 2 wds. |
| 45% | ALTHEAGIBSON | 12 | First African-American woman to win the Women's Singles championship at Wimbledon (2 wds.) |
| 45% | MICHELLEOBAMA | 13 | First African-American woman to serve as First Lady of the United States (2 wds.) |
| 45% | TONIMORRISON | 12 | First African-American woman to win the Nobel Prize for Literature (2 wds.) |
| 44% | MARIE | 5 | ___ Maynard Daly, the first African American woman to earn a Ph.D. in chemistry |
| 44% | DOUGWILLIAMS | 12 | First African American quarterback to be named 44-Across, in 1988: 2 wds. |
| 44% | NEWYORK | 7 | American city where The Beatles first landed in 1964: 2 wds. |
| 43% | MAE | 3 | ___ Jemison, first African-American woman in space |
| 43% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize in Literature, in 1938: 3 wds. |
| 43% | TONIMORRISON | 12 | "Beloved" author who died August 5, and who was the first African-American woman to win a Nobel Prize: 2 wds. |
| 43% | SALLYRIDE | 9 | First American woman to travel into space (1983): 2 wds. |