| 100% | HARPERS | 7 | First American magazine to excerpt "Moby-Dick" |
| 46% | NEMESIS | 7 | Moby Dick, to Ahab |
| 45% | GLENN | 5 | First American to orbit Earth |
| 44% | EDWHITE | 7 | First American to walk in space |
| 44% | JOHNGLENN | 9 | First American to orbit the Earth |
| 44% | GLENN | 5 | First American to orbit the Earth |
| 44% | GGLLEENNNN | 10 | First American to orbit the earth |
| 44% | GRISSOM | 7 | First American to go into space twice |
| 43% | TWA | 3 | First American carrier to show movies on flights |
| 43% | STL | 3 | First American city to host the Olympics, initially |
| 42% | ALANSHEPARD | 11 | First American to travel into space (1961): 2 wds. |
| 42% | JOHNGLENN | 9 | First American to orbit the earth (1962): 2 wds. |
| 42% | SHEPARD | 7 | Alan __; first American to travel to space |
| 42% | JOHNGLENN | 9 | The first American to orbit the Earth |
| 42% | GLENN | 5 | John, first American to orbit the planet |
| 42% | EBONY | 5 | Magazine targeted to African Americans |
| 42% | INC | 3 | First national magazine to feature Steve Jobs on the cover |
| 41% | SALLYRIDE | 9 | First American woman to travel into space (1983): 2 wds. |
| 41% | GLENN | 5 | John, the first American to orbit the Earth |
| 41% | EBONY | 5 | Magazine to which Obama gave his first postelection interview in 2008 |
| 41% | TWA | 3 | First American carrier to regularly show movies on flights, for short |
| 41% | MIRAINAGASU | 11 | First American woman to land a triple axel at the Olympics |
| 40% | RETTON | 6 | First American woman to win the all-around gold in Olympic gymnastics |
| 40% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize for Literature (3 wds.) |
| 40% | RETTON | 6 | First American woman to win all-around gymnastics gold at the Olympics |
| 40% | GLENN | 5 | John who was the first American to orbit the earth |
| 40% | SALLYRIDE | 9 | The first American woman to travel to space |
| 39% | ALANSHEPARD | 11 | First American to travel into space during NASA's 1961 Freedom 7 mission |
| 39% | SUNISALEE | 9 | First Hmong American to win an Olympic gold medal |
| 39% | WEBDUBOIS | 9 | First Black American to get a PhD from Harvard |