| 100% | BILLIEEILISH | 12 | First artist born in the two-thousands to reach No. 1 on the Billboard Hot 100 (August, 2019) |
| 63% | ANNEMURRAY | 10 | First Canadian female solo artist to reach No. 1 on the U.S. Billboard Hot 100 |
| 57% | DESPACITO | 9 | 2017 hit that was the first Spanish-language song to reach No. 1 on the Billboard Hot 100 since "Macarena" |
| 50% | KIMPETRAS | 9 | First openly transgender woman to have a No. 1 song on the Billboard Hot 100 chart |
| 49% | CARRIEUNDERWOOD | 15 | Country artist who debuted at No. 1 on the Billboard Hot 100 |
| 49% | BORN | 4 | "___ This Way" (Lady Gaga hit that was the 1,000th song to reach No. 1 on the "Billboard" Hot 100 chart) |
| 48% | MARIAHCAREY | 11 | Five-time Grammy winner who is the only artist whose first five singles reached #1 on the Billboard Hot 100 (2 wds.) |
| 47% | WATERMELONSUGAR | 15 | Harry Styles’s first No. 1 single on the Billboard Hot 100 (August, 2020) |
| 46% | DREAM | 5 | "Teenage ___," 2010 song by Katy Perry that reached No. 1 on the Billboard Hot 100 |
| 46% | ICEICEBABY | 10 | First single by a rapper to reach #1 on the Billboard Hot 100 |
| 46% | WHAT | 4 | "___ a Girl Wants," 1999 song by Christina Aguilera that reached No. 1 on the Billboard Hot 100 |
| 44% | ISLANDSIN | 9 | "___ the Stream," a song by Kenny Rogers - whose birthday it is today - and Dolly Parton which reached No.1 on the Billboard Hot 100: 3 wds. |
| 44% | ILL | 3 | Licensed to ____ (first rap album to reach No. 1 on the Billboard 200 chart) |
| 44% | LONDONBRIDGE | 12 | Fergie song that reached #1 on the Billboard Hot 100 in the summer of 2006: 2 wds. |
| 44% | PROMISCUOUS | 11 | Nelly Furtado/Timbaland song that reached #1 on the Billboard Hot 100 in the summer of 2006 |
| 44% | OLIVIARODRIGO | 13 | Singer whose debut single "Drivers License" reached #1 on the Billboard Hot 100 in 2021: 2 wds. |
| 43% | HIPSDONTLIE | 11 | Shakira/Wyclef Jean song that reached #1 on the Billboard Hot 100 in the summer of 2006: 3 wds. |
| 43% | KELLYCLARKSON | 13 | Singer whose debut single "A Moment Like This" reached #1 on the Billboard Hot 100 in 2002: 2 wds. |
| 43% | MEGHANTRAINOR | 13 | Singer whose debut single "All About That Bass" reached #1 on the Billboard Hot 100 in 2014: 2 wds. |
| 42% | THISISAMERICA | 13 | Donald Glover (as Childish Gambino) song that spent two weeks at #1 on the Billboard Hot 100 in 2018 (3 wds.) |
| 42% | SENORITA | 8 | 2019 song by Shawn Mendes and Camila Cabello which reached number one on the Billboard Hot 100 |
| 42% | BOO | 3 | "My ___," duet between Alicia Keys and Usher that peaked at No. 1 on the Billboard Hot 100 |
| 42% | IMMA | 4 | "___ Be," 2009 song by the Black Eyed Peas that peaked at No. 1 on the Billboard Hot 100 |
| 42% | FEELING | 7 | "I Gotta ___," 2009 song by the Black Eyed Peas that peaked at No. 1 on the Billboard Hot 100 |
| 41% | CARRIEUNDERWOOD | 15 | First country artist to debut atop the Billboard Hot 100 chart |
| 41% | SIA | 3 | Artist whose “Unstoppable” appeared on the Billboard Hot 100 in 2022, six years after its release |
| 41% | ESPRESSO | 8 | Sabrina Carpenter hit song that peaked at No. 3 on the Billboard Hot 100 in 2024 |
| 41% | ERNIE | 5 | Muppet whose song “Rubber Duckie” reached No. 16 on the Billboard Hot 100 |
| 40% | ROBOTO | 6 | "Mr. ___," 1983 single by Styx that reached No. 3 on the Billboard Hot 100 |
| 40% | SKYFALL | 7 | 2012 Adele hit that was the first James Bond theme to debut in the top 10 on Billboard's Hot 100 |