| 100% | DARKOFTHEMOON | 13 | First book in a series of novels by John Sandford featuring 46-Across (4 wds.) |
| 54% | TWILIGHT | 8 | First book in a series of vampire novels by Stephenie Meyer |
| 51% | RAMONATHEPEST | 13 | One in a series of books by 46-Across about a girl starting kindergarten: 3 wds. |
| 51% | HENRYANDRIBSY | 13 | One in a series of books by 46-Across about a boy and his dog: 3 wds. |
| 51% | HOLYGHOST | 9 | 2018 novel by John Sandford featuring 46-Across (2 wds.) |
| 50% | HOLYGHOST | 9 | Book by John Sandford which was part of the "Virgil Flowers" novel series and became a NYT 2018 Bestseller: 2 wds. |
| 49% | TESSMONAGHAN | 12 | Reporter-turned-investigator in a series of novels by 44-Across (2 wds.) |
| 47% | MYRONBOLITAR | 12 | Fictional basketball player-turned-sports agent who solves mysteries in a series of novels by 35-Across (2 wds.) |
| 47% | EVEDUNCAN | 9 | Forensic sculptor in a series of novels by Iris Johansen (2 wds.) |
| 46% | CORKOCONNOR | 11 | Former small-town sheriff featured in a series of novels by William Kent Krueger, including "Iron Lake," 18-Across, and 29-Across (2 wds.) |
| 46% | TESSMONAGHAN | 12 | Reporter-turned-investigator in a series of crime novels by 44-Across (2 wds.) |
| 44% | WITCHSSISTER | 12 | First book in a fantasy series about black magic by Phyllis Reynolds Naylor (2 wds.) |
| 43% | ARMANDGAMACHE | 13 | Chief inspector in a series of mystery novels by Louise Penny (2 wds.) |
| 42% | WAYSIDESCHOOL | 13 | Setting for a series of novels by 30-Across (2 wds.) |
| 42% | THEROGUECREW | 12 | Last book in the "Redwall" series of children's fantasy novels by 50-Across (3 wds.) |
| 41% | WALTLONGMIRE | 12 | Sheriff of the fictional county of Absaroka, Wyoming, who is featured in 20 books by 40-Across and a 2012-2017 television series (2 wds.) |
| 39% | CAMPTIGER | 9 | Children's book by 52-Across and illustrator John Rocco that features a big cat in the woods (2 wds.) |
| 39% | CASCA | 5 | Roman soldier in a series of novels by Barry Sadler beginning with 1979's The Eternal Mercenary |
| 39% | THESCHOLOMANCE | 14 | Trilogy of novels by 27-Across set in a magic school (2 wds.) |
| 39% | ENDER | 5 | Protagonist in a series of books by 11-Down |
| 38% | LORDBROCKTREE | 13 | First book (chronologically) in the "Redwall" series by 50-Across (2 wds.) |
| 38% | SIXTEEN | 7 | Next number in a series suggested by the starts of 17-, 27-, 46- and 60-Across |
| 37% | DIVINEJUSTICE | 13 | Fourth novel in a series featuring Oliver Stone and his group of political watchdogs called the Camel Club (2 wds.) |
| 37% | SALLY | 5 | "The Adventures of ___," novel by P.G. Wodehouse first published as a book in 1922 |
| 37% | MALORY | 6 | "___ Towers," series of novels by Enid Blyton that is set in a girls' boarding school |
| 37% | TOPSY | 5 | Title twin sister in a series of children's books by Jean and Gareth Adamson |
| 36% | OLIVIA | 6 | Pig featured in a series of children's books |
| 36% | VIRGILFLOWERS | 13 | Criminal investigator featured in 11 John Sandford novels who began as a supporting character in Sandford's "Prey" series of novels (2 wds.) |
| 36% | RABBITRUN | 9 | First in a John Updike novel series |
| 35% | EARTHSEACYCLE | 13 | Series of high fantasy novels and stories by 44-Across set on an otherworldly archipelago in an uncharted ocean (2 wds.) |