| 100% | TWILIGHT | 8 | First book in a series of vampire novels by Stephenie Meyer |
| 64% | DARKOFTHEMOON | 13 | First book in a series of novels by John Sandford featuring 46-Across (4 wds.) |
| 52% | TWILIGHT | 8 | 2005 novel by Stephenie Meyer featuring vampires that was adapted into a film series starring Robert Pattinson |
| 48% | ENDER | 5 | Protagonist in a series of books by 11-Down |
| 46% | EVEDUNCAN | 9 | Forensic sculptor in a series of novels by Iris Johansen (2 wds.) |
| 46% | WITCHSSISTER | 12 | First book in a fantasy series about black magic by Phyllis Reynolds Naylor (2 wds.) |
| 46% | TESSMONAGHAN | 12 | Reporter-turned-investigator in a series of novels by 44-Across (2 wds.) |
| 46% | ARMANDGAMACHE | 13 | Chief inspector in a series of mystery novels by Louise Penny (2 wds.) |
| 45% | TOPSY | 5 | Title twin sister in a series of children's books by Jean and Gareth Adamson |
| 45% | RAMONATHEPEST | 13 | One in a series of books by 46-Across about a girl starting kindergarten: 3 wds. |
| 45% | TWILIGHT | 8 | Vampire book series by Stephenie Meyer |
| 44% | CASCA | 5 | Roman soldier in a series of novels by Barry Sadler beginning with 1979's The Eternal Mercenary |
| 44% | HENRYANDRIBSY | 13 | One in a series of books by 46-Across about a boy and his dog: 3 wds. |
| 44% | MYRONBOLITAR | 12 | Fictional basketball player-turned-sports agent who solves mysteries in a series of novels by 35-Across (2 wds.) |
| 43% | SALLY | 5 | "The Adventures of ___," novel by P.G. Wodehouse first published as a book in 1922 |
| 43% | TESSMONAGHAN | 12 | Reporter-turned-investigator in a series of crime novels by 44-Across (2 wds.) |
| 42% | GOT | 3 | First book in the series "A Song of Ice and Fire," familiarly |
| 42% | DIVERGENT | 9 | First book in a trilogy by Veronica Roth |
| 42% | MALORY | 6 | "___ Towers," series of novels by Enid Blyton that is set in a girls' boarding school |
| 42% | CORKOCONNOR | 11 | Former small-town sheriff featured in a series of novels by William Kent Krueger, including "Iron Lake," 18-Across, and 29-Across (2 wds.) |
| 41% | THEROGUECREW | 12 | Last book in the "Redwall" series of children's fantasy novels by 50-Across (3 wds.) |
| 41% | ELOISE | 6 | Plaza resident in a series of books |
| 41% | BABAR | 5 | Elephant in a series of over 40 books |
| 41% | ALFA | 4 | First in a series of 26 |
| 41% | OPENER | 6 | First in a series of events |
| 40% | DRFUMANCHU | 10 | *Sinister genius in a series of Sax Rohmer novels |
| 40% | HARRYHOLE | 9 | Detective in a series of Jo Nesbø crime novels |
| 40% | OLIVIA | 6 | Pig featured in a series of children's books |
| 40% | ELMER | 5 | Patchwork elephant in a series of children's books |
| 40% | RAMONA | 6 | Title character in a series of Beverly Cleary books |