| 100% | SPICEGIRLS | 10 | First British group since the Beatles to have two albums in the U.S. top 10 at the same time |
| 31% | BIGAMY | 6 | Having two spouses at the same time |
| 29% | SCOFF | 5 | Nirvana's debut album in 1989 that contained song, may have caused some laughter at the time |
| 29% | MAHERSHALAALI | 13 | First black actor to win two Oscars in the same category, and only the second to win two competitive Oscars: 2 wds. |
| 29% | WARRENGHARDING | 14 | U.S. president who, in 1922, became the first president to have his voice transmitted on the radio (3 wds.) |
| 29% | JOSEFELICIANO | 13 | His 1970 song "Feliz Navidad" hit the top 10 for the first time ever in 2020: 2 wds. |
| 29% | AHA | 3 | First Norwegian band to have a #1 hit in the US: Hyph. |
| 29% | CHUCKBERRY | 10 | His 1958 song "Run Rudolph Run" hit the top 10 for the first time ever in 2021: 2 wds. |
| 29% | CARNATIONS | 10 | Flowers that have represented Mother's Day since 17a delivered 500 of them at the first celebration in 1908 |
| 29% | SONIC | 5 | First video game character to have a balloon in the Macy's Thanksgiving Day Parade |
| 29% | LAWNDARTS | 9 | Outdoor game whose sale has been banned in the U.S. since 1988 |
| 29% | ROSAPARKS | 9 | First woman to lie in honor in the U.S. Capitol |
| 28% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 28% | IVE | 3 | "___ Gotta Get a Message to You" (first U.S. Top 10 hit for the Bee Gees) |
| 28% | SKYFALL | 7 | 2012 Adele hit that was the first James Bond theme to debut in the top 10 on Billboard's Hot 100 |
| 28% | PALMSPRINGS | 11 | California city that, in 2018, became the first U.S. city to have an all-L.G.B.T. city council |
| 28% | ZOO | 3 | Philadelphia had the first one in the U.S. (1874) |
| 28% | STREISAND | 9 | Only artist to have a #1 album in every decade since the 1960s |
| 28% | PSYCHO | 6 | Film where Marion was shown flushing a toilet with its contents visible - a first in the US at the time |
| 28% | TWINS | 5 | Two siblings born at the same time |
| 28% | LAPD | 4 | First law enforcement org. in the U.S. to hire a female officer (1910) |
| 27% | FAKELOVE | 8 | 2018 BTS hit that was their first top 10 single in the US: 2 wds. |
| 27% | ANNI | 4 | ___ Albers, first textile designer to have a solo exhibition at the MoMA in NYC (1949) |
| 27% | NWA | 3 | Group that had the first hardcore rap album to reach #1 on Billboard |
| 27% | SUNBELT | 7 | Home to eight of the 10 fastest-growing cities in the U.S. |
| 27% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 27% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 27% | SYNC | 4 | Cause to occur at the same time |
| 27% | USN | 3 | JFK was the first president to have served in this branch of the US Armed Forces |
| 27% | DEANMARTIN | 10 | His 1959 song "Let It Snow! Let It Snow! Let It Snow!" hit the top 10 for the first time ever in 2021: 2 wds. |