| 100% | ELLENOCHOA | 10 | First Hispanic woman in space, aboard the space shuttle Discovery in 1993: 2 wds. |
| 71% | MAEJEMISON | 10 | First African-American woman in space, aboard the space shuttle Endeavour in 1992: 2 wds. |
| 48% | SALLYRIDE | 9 | First American woman in space: 2 wds. |
| 48% | OCHOA | 5 | Astronaut Ellen who was the first Hispanic woman in space |
| 46% | JANEADDAMS | 10 | First American woman to be awarded the Nobel Peace Prize, in 1931: 2 wds. |
| 45% | EILEENCOLLINS | 13 | First female commander of a space shuttle, Columbia in 1999: 2 wds. |
| 45% | FRANCESARNOLD | 13 | First American woman to win the Nobel Prize in Chemistry, in 2018: 2 wds. |
| 44% | KALPANACHAWLA | 13 | Indian American astronaut aboard the ill-fated Space Shuttle Columbia in 2003 who was on her second mission on the same shuttle: 2 wds. |
| 42% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 41% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 41% | BECKYHAMMON | 11 | First woman to act as head coach in an NBA game, for the San Antonio Spurs in 2020: 2 wds. |
| 41% | DEBBIEHARRY | 11 | Lead singer of Blondie who received the first Billboard Women in Music Icon Award, in 2008: 2 wds. |
| 41% | MAE | 3 | The first black woman in space __ Jemison |
| 41% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 41% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 41% | VENUSWILLIAMS | 13 | First African-American woman to hold the world #1 ranking in tennis's Open era: 2 wds. |
| 40% | VENUSWILLIAMS | 13 | First African-American tennis player to be ranked #1 in women's singles during the Open Era: 2 wds. |
| 40% | SALLYRIDE | 9 | She was the first American woman in Space |
| 40% | SPACELAB | 8 | Microgravity laboratory first flown into space on the Space Shuttle Columbia in 1983 |
| 40% | KATIESOWERS | 11 | First woman in the NFL to coach in a Super Bowl, for the San Francisco 49ers in 2020: 2 wds. |
| 39% | MAE | 3 | Jemison who was the first Black woman in space |
| 39% | JEMISON | 7 | Mae who was the first Black woman in space |
| 39% | SALLY | 5 | ___ Ride who was the first American woman in space |
| 39% | VANESSAKIRBY | 12 | "The Crown" actress who plays Invisible Woman in "The Fantastic Four: First Steps": 2 wds. |
| 39% | RIDE | 4 | Astronaut Sally who was the first American woman in space |
| 39% | MAE | 3 | Astronaut Jemison who was the first Black woman in space |
| 39% | RIDE | 4 | She became the first American woman in space in 1983 |
| 39% | MARGARETCOURT | 13 | Australian tennis player who was the first woman to win the Grand Slam in the Open Era: 2 wds. |
| 39% | ALYSSANAKKEN | 12 | First woman to coach on the field of a Major League Baseball game, for the San Francisco Giants in 2020: 2 wds. |
| 38% | VALENTINA | 9 | Tereshkova, the first woman in space in 1963 |