| 100% | EARLIEST | 8 | First in time |
| 75% | END | 3 | First Sunday in November, for daylight saving time |
| 74% | PLEISTOCENE | 11 | First epoch of the Quaternary period in geological time |
| 71% | BRAD | 4 | First name in the Once Upon a Time in ... Hollywood cast |
| 71% | ELSA | 4 | "For the First Time in Forever" duettist |
| 69% | YEARDOT | 7 | The first place in time; forever |
| 68% | LPS | 3 | In 2020, they outsold CDs for the first time since 1986 |
| 68% | GUIDO | 5 | First name adopted by Guy Fawkes during his time in Spain |
| 68% | OPED | 4 | The first one in The New York Times appeared in 1970 |
| 68% | ONCEUPON | 8 | __ a time, first four words in most fairy tales |
| 68% | CENTRAL | 7 | Alphabetically first time zone in the contiguous U.S. |
| 67% | AGASSI | 6 | Andre ___, first male player to win tournament mentioned in 17a four times |
| 66% | SWUM | 4 | Like the English Channel for the first time in 1875 |
| 66% | USPOSTAGE | 9 | It fell in 2016 for the first time since 1919 |
| 66% | GRAYHOLE | 8 | Outer space phenomenon photographed for the first time in 2019 |
| 65% | SAUDI | 5 | ___ Arabia (nation where women voted for the first time in 2015) |
| 65% | COEDS | 5 | Some University of Virginia undergrads in 1969, for the first time |
| 65% | ASIA | 4 | Where the Olympics were held for the first time in 1964 |
| 65% | BARBIE | 6 | Doll that ran for president for the first time in 1992 |
| 65% | POI | 3 | Food that tourists in Hawaii often try for the first time |
| 65% | WOMENSWORLDCUP | 14 | FIFA event held for the first time in 1991 (3 wds.) |
| 64% | JENNABUSHHAGER | 14 | Former First Daughter who wrote the memoir "Everything Beautiful in Its Time" (3 wds.) |
| 64% | FLIES | 5 | In the musical "Wicked," what Elphaba does for the first time during "Defying Gravity" |
| 64% | SPLITTINGTHEATOM | 16 | Scientific feat first accomplished in 1932, as well as seven times in this puzzle |
| 64% | LUAU | 4 | Party where tourists in Hawaii might try poi for the first time |
| 64% | RADIO | 5 | It was used to play music for the first time in 1906 |
| 64% | ELSA | 4 | One of two Disney characters singing "For the First Time in Forever" |
| 63% | TOOLATE | 7 | Not in time |
| 63% | AFTER | 5 | Following in time |
| 63% | AGO | 3 | Back in time |