| 100% | SIGEP | 5 | First national fraternity to officially welcome transgender members (2014), informally |
| 30% | LIA | 3 | ___ Thomas, first openly transgender athlete to win an NCAA Division I national championship (swimming) |
| 28% | OTT | 3 | First National Leaguer to hit 500 home runs |
| 28% | PANERA | 6 | First national restaurant chain to post calorie counts |
| 27% | ACLU | 4 | First national org. to call for Richard Nixon's impeachment |
| 27% | INC | 3 | First national magazine to feature Steve Jobs on the cover |
| 27% | UNDIES | 6 | First clothing to put on, informally |
| 25% | DAD | 3 | ''The First National Bank of __'' (book to teach kids about money) |
| 25% | TAFT | 4 | First president to be buried at Arlington National Cemetery |
| 25% | RBG | 3 | Clinton's first appointee to the Supreme Court, informally |
| 25% | RBG | 3 | First member of SCOTUS to officiate a same-sex wedding |
| 24% | TWO | 3 | First digit in the year we're about to welcome: 2025 |
| 24% | ARMENIAN | 8 | Member of the first state to adopt Christianity as its religion |
| 24% | CONDOLEEZZARICE | 15 | One of Augusta National's first two female members |
| 24% | TEC | 3 | Religious org. of Rev. Cameron Partridge, first openly transgender priest to preach at Washington's Natl. Cathedral (2014) |
| 24% | MALIK | 5 | Surname of the first member to leave One Direction |
| 24% | ZAILAAVANTGARDE | 15 | First African American to win the Scripps National Spelling Bee |
| 23% | ACLU | 4 | Legal organization that defended transgender military members' right to serve: Abbr. |
| 22% | ORANGUTANS | 10 | In 2014 Argentina became the first country to recognize these primates' legal rights |
| 22% | KIMPETRAS | 9 | First openly transgender woman to have a No. 1 song on the Billboard Hot 100 chart |
| 21% | JESMYNWARD | 10 | In 2017, she became the first woman to win two National Book Awards for fiction |
| 21% | DAWN | 4 | ___ Braid, first woman to hold a full-time coaching job in the National Hockey League |
| 21% | UPTOWNFUNK | 10 | 2014 Mark Ronson hit that later had to give members of the Gap Band songwriting credits: 2 wds. |
| 21% | DONN | 4 | ___ Tatum, the first non-Disney famiy member to be the chairman of The Walt Disney Company |
| 20% | MEL | 3 | With 26-Across, first National Leaguer to hit 500 home runs |
| 20% | COLDPLAY | 8 | First band to surpass one billion streams on Spotify (2014) |
| 20% | SANDIEGOWAVEFC | 14 | National Women's Soccer League expansion team in California expected to play its first game in 2022 (4 wds.) |
| 20% | FROMTHEROUGH | 12 | 2014 film starring Taraji P. Henson as the first woman to coach a men's golf team (3 wds.) |
| 20% | ALPHABET | 8 | Series whose first seven members are sung to the starts of 18-, 26-, 41- and 54-Across |
| 20% | OTT | 3 | First National Leaguer with 500 homers |