| 100% | KIMPETRAS | 9 | First openly transgender woman to have a No. 1 song on the Billboard Hot 100 chart |
| 44% | DESPACITO | 9 | 2017 hit that was the first Spanish-language song to reach No. 1 on the Billboard Hot 100 since "Macarena" |
| 43% | ICEICEBABY | 10 | First single by a rapper to reach #1 on the Billboard Hot 100 |
| 43% | CHER | 4 | The only artist to have a #1 song on a Billboard chart in six consecutive decades |
| 43% | ANNAKENDRICK | 12 | Actress who had a song from "Pitch Perfect" chart on the Billboard Hot 100 in 2013: 2 wds. |
| 43% | WATERMELONSUGAR | 15 | Harry Styles’s first No. 1 single on the Billboard Hot 100 (August, 2020) |
| 42% | WHITNEYHOUSTON | 14 | Only singer to have seven consecutive #1 singles on the Billboard Hot 100 |
| 42% | ANNEHATHAWAY | 12 | Actress who had a song from "Les Misérables" chart on the Billboard Hot 100 in 2013: 2 wds. |
| 42% | BILLIEEILISH | 12 | First artist born in the two-thousands to reach No. 1 on the Billboard Hot 100 (August, 2019) |
| 42% | POPTUNE | 7 | Many a song on the Billboard Hot 100 |
| 41% | BRADLEYCOOPER | 13 | Actor who had a song from "A Star Is Born" chart on the Billboard Hot 100 in 2018: 2 wds. |
| 41% | OATES | 5 | Half of the duo that has had six No. 1 hits on the Billboard Hot 100 |
| 41% | THEWEEKND | 9 | "Starboy" pop singer who had 18 songs on the Billboard Hot 100 during a week in 2016: 2 wds. |
| 40% | WHAT | 4 | "___ a Girl Wants," 1999 song by Christina Aguilera that reached No. 1 on the Billboard Hot 100 |
| 39% | FANTASTIC | 9 | "___ Voyage," 1994 song by Coolio that reached No. 3 on the Billboard Hot 100 chart |
| 39% | ANNEMURRAY | 10 | First Canadian female solo artist to reach No. 1 on the U.S. Billboard Hot 100 |
| 38% | HERBALPERT | 10 | Only musician to hit #1 on the Billboard Hot 100 as both a vocalist and an instrumentalist |
| 38% | SNOW | 4 | "___ (Hey Oh)," 2006 Red Hot Chili Peppers song that was a No. 1 hit on the Billboard Modern Rock chart |
| 37% | FROZEN | 6 | 1998 song by Madonna that peaked at No. 2 on the Billboard Hot 100 with lyrics about a cold and emotionless man |
| 37% | CARRIEUNDERWOOD | 15 | First country artist to debut atop the Billboard Hot 100 chart |
| 37% | LUCKY | 5 | "Get ___," 2013 song by Daft Punk that peaked at No. 2 on the Billboard Hot 100 chart |
| 37% | BORN | 4 | "___ This Way" (Lady Gaga hit that was the 1,000th song to reach No. 1 on the "Billboard" Hot 100 chart) |
| 37% | CHER | 4 | The oldest woman to have a #1 Billboard hit |
| 36% | DREAM | 5 | "Teenage ___," 2010 song by Katy Perry that reached No. 1 on the Billboard Hot 100 |
| 36% | UPSIDEDOWN | 10 | 1980 50-Across song that hit #1 on the Billboard Hot 100, Disco, and Soul charts (2 wds.) |
| 35% | SUCKER | 6 | 2019 song by the Jonas Brothers, which featured on the Billboard Hot 100 chart |
| 35% | ZAYN | 4 | British singer who topped the Billboard Hot 100 chart with the song "Pillowtalk" |
| 35% | CARRIEUNDERWOOD | 15 | Country artist who debuted at No. 1 on the Billboard Hot 100 |
| 35% | SEAN | 4 | Jay ___, British singer who topped the Billboard Hot 100 chart with the song "Down" |
| 35% | MADONNA | 7 | 2012's "Give Me All Your Luvin'" was her 38th top-10 hit on the Billboard Hot 100 chart |