| 100% | CRONKITE | 8 | First person outside NASA to receive a moon-rock award, 2006 |
| 46% | DEAN | 4 | First person to receive a posthumous Academy Award for Best Actor nomination |
| 35% | ANGLEE | 6 | First nonwhite person to win a directing Oscar, in 2006 |
| 34% | TESTPILOT | 9 | First person to fly a plane |
| 34% | MARIECURIE | 10 | First person to receive two Nobel Prizes |
| 34% | ARMSTRONG | 9 | First person to walk on the moon |
| 33% | NEIL | 4 | First person to walk on the moon, Armstrong |
| 33% | JOHNYOUNG | 9 | First person to fly solo around the Moon |
| 33% | OCTAVIAEBUTLER | 14 | First science fiction writer to receive a MacArthur Fellowship |
| 33% | GALILEO | 7 | First person to use a telescope to study space |
| 32% | NEILARMSTRONG | 13 | First person to walk on the moon (1969): 2 wds. |
| 32% | CHRISTIAANBARNYARD | 18 | First person to perform a heart transplant on a chicken? |
| 32% | NEIL | 4 | ___ Armstrong, first person to walk on the moon |
| 32% | ARMSTRONG | 9 | Neil, the first person to walk on the moon |
| 32% | ARMSTRONG | 9 | Neil, the first person to step on the moon |
| 32% | ALEKSEI | 7 | Cosmonaut Leonov, the first person to conduct a spacewalk |
| 32% | COMANECI | 8 | First Olympic gymnast to receive a 10 |
| 31% | HONOREE | 7 | Person receiving a key to the city, perhaps |
| 30% | ELVIS | 5 | First rock star to appear on a U.S. stamp |
| 30% | LUISE | 5 | Rainer who was the first person to win two Academy Awards for acting |
| 30% | ULRIC | 5 | German prelate who was the first person to be canonized, A.D. 993 |
| 30% | OCTAVIABUTLER | 13 | First science-fiction author to receive a MacArthur “genius” grant |
| 30% | YALE | 4 | First U.S. university to award a Ph.D. |
| 30% | COMANECI | 8 | Nadia __, first gymnast to be awarded a perfect 10 |
| 30% | KISSCAM | 7 | What sends people to first base at a game? |
| 30% | JKROWLING | 9 | First person to win a Smarties Prize, for children's books, three years in a row |
| 30% | DIAMONDJIMBRADY | 15 | Tycoon who was the first person in New York City to own a car |
| 30% | OMAR | 4 | Ilhan who was the first person to wear a hijab on the House floor |
| 29% | OCTAVIABUTLER | 13 | First science-fiction writer to be awarded a MacArthur grant |
| 29% | SERIAL | 6 | First podcast to win a Peabody Award (2015) |