| 100% | SNL | 3 | First show to win 50 Emmys, in brief |
| 44% | TKOD | 4 | Walloped to win the bout, in brief |
| 43% | DIOMED | 6 | First horse to win the Epsom Derby in 1780 |
| 42% | JOHNNYMANZIEL | 13 | First freshman to win the 15-Across, in 2012: 2 wds. |
| 40% | NKJEMISIN | 9 | First author to win a Hugo Award for every book in a trilogy |
| 39% | CLARESSASHIELDS | 15 | First American to win back-to-back Olympic gold medals in boxing, in 2012 and 2016 |
| 39% | JKROWLING | 9 | First person to win a Smarties Prize, for children's books, three years in a row |
| 38% | SHOGUN | 6 | Show that won a record-breaking 18 Emmys in a single year |
| 38% | MADMEN | 6 | First basic cable show to win an Emmy for Outstanding Drama Series |
| 38% | BERNIEPARENT | 12 | First player to win the NHL's Conn Smythe Trophy in consecutive years (1974, 1975) (2 wds.) |
| 38% | GAMEOFTHRONES | 13 | Show with the record for most Emmys won in a single year (12) |
| 37% | DOUG | 4 | ___ Williams, first Black quarterback to start in, and win, a 15 Across |
| 37% | BOB | 3 | ___ Dylan, first musician to win the Nobel Prize in Literature |
| 37% | ANGLEE | 6 | First nonwhite person to win a directing Oscar, in 2006 |
| 37% | MORRISON | 8 | First Black woman to win the Nobel Prize in Literature |
| 37% | THEXFILES | 9 | First Fox show to finish in Nielsen's top 20 for a season |
| 36% | RHODA | 5 | First TV show to debut at #1 in the Nielsen ratings |
| 36% | UNITAS | 6 | Winning QB in the first N.F.L. playoff game to go into sudden-death overtime |
| 36% | CAMEO | 5 | Term used to describe a brief appearance by a celebrity in a TV show |
| 36% | WINNIE | 6 | ___ Harlow, first model with vitiligo to walk in the Victoria's Secret Fashion Show |
| 36% | RETTON | 6 | First American woman to win the all-around gold in Olympic gymnastics |
| 35% | UTA | 3 | ___ Pippig, first woman to win the Boston Marathon three times in a row |
| 35% | FRANCESARNOLD | 13 | First American woman to win the Nobel Prize in Chemistry, in 2018: 2 wds. |
| 35% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize in Literature, in 1938: 3 wds. |
| 35% | OERTER | 6 | Al ___, first athlete to win gold in same individual event in four successive Olympics |
| 34% | HARRY | 5 | ___ Johnson and Beaux Raymond, TV personalities who won the reality show "Too Hot to Handle" in 2022 |
| 34% | SARAZEN | 7 | First golfer to win all four majors |
| 34% | SADAT | 5 | First Egyptian to win a Nobel Prize |
| 34% | CURIE | 5 | First woman to win the Nobel Prize |
| 34% | BIGELOW | 7 | First female to win best director Oscar |